CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD664
Family Name Beta-1 adrenergic receptor Ligand Practolol Family
No. of Seeds 2 No. of Other Members 82
Family Centroid CFAMM00093276 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Beta-1 adrenergic receptor Ligand Practolol Superfamily
Class Class 516

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Cyclooxygenase Inhibitor Acetaminophen Family 2 42
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 7
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Transforming growth factor-beta Inhibitor ACE-011 Family 1 13
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
Liver carboxylesterase 1 Inhibitor CI-976 Family 1 32
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Histamine H3 receptor Ligand UCL1972 Family 3 23
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Carbonic anhydrase 2 Inhibitor 4-methoxyphenylsulfamide Family 2 27
Histone deacetylase 1 Inhibitor 7-(4-(dimethylamino)phenoxy)-n... 2 1
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor 6... 2 0
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 10 4
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THW family 1 0
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor SureCN... 2 11
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 6 11
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
C-C chemokine receptor type 1 ligand N-[2-[(2S)-3-(5-chlorospi... 4 0
Angiotensin-converting enzyme inhibitor AGN-PC-076HUS family 2 3
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 8
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 3 0
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 1 4
Neutrophil elastase inhibitor AGN-PC-04S1IE family 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
Lysophosphatidic acid receptor 2 and Lysophosphatidic acid rec... 1 0
Amyloid beta A4 protein inhibitor 2-(fluoranylmethyl)-3-[4-[(E... 1 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Hormone-sensitive lipase and Acetylcholinesterase inhibitor Su... 2 0
Beta-1 adrenergic receptor and Beta-3 adrenergic receptor liga... 2 0
Cathepsin K inhibitor N-[2-(4-methoxyanilino)ethyl]-4-methyl-2... 1 1
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 3
Nitric oxide synthase, brain inhibitor AC1PDE4K family 4 1
Benzoxazoles Metabolite 2-Hydroxy-6,7-dimethoxybenzoxazole Family 1 5
Benzoxazines Metabolite 2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxa... 5 1
NP (2r,3s,4r,5r,6s)-5-acetamido-2-(acetoxymethyl)-6-(3-nitroph... 5 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00093276 DAP000940 Approved Drug Practolol
CFAMM00093292 DNC000790 Investigative Drug Imidazo[4,5-e][1, 4]diazapine nucleotide (I)

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23731 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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