CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD665
Family Name Beta-1 adrenergic receptor Ligand Nebivolol Family
No. of Seeds 5 No. of Other Members 22
Family Centroid CFAMM00093400 Functional Category Approved Drug with Natural Product
Superfamily monoamine reuptake and receptor binding Fluoxetine Reboxetine Bevantolol Nebivolol Superfamily
Class Class 149

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta adrenergic receptor Ligand Metipranolol Family 5 1
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
Vernakalant family 1 1
Acolbifene family 10 115
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Extracellular calcium-sensing receptor and Potassium voltage-g... 3 11
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Renin Inhibitor Ro-65-7219 Family 10 8
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 1A Ligand Tertatolol Family 1 1
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
D(4) dopamine receptor ligand AGN-PC-0073PO family 7 10
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 3
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Squalene synthase inhibitor 3-[4-[[(E)-ethylideneamino]oxymeth... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 7 4
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 5 4
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 2 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 6 21
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 2 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL1... 5 5
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 1 0
5-hydroxytryptamine receptor 1A ligand oxalic acid;(1R,5S)-5-[... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 0
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 14 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 3 7
Sodium-dependent serotonin transporter and Histamine H3 recept... 13 2
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 10 8
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 5
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 0
Sodium-dependent noradrenaline transporter and Cytochrome P450... 11 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Muscleblind-like protein 1 and Ferritin light chain inhibitor ... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Cytochrome P450 2D6 and Sodium channel protein type 1 subunit ... 1 1
NP 1-(7-hydroxyspiro[chroman-2,4'-piperidin]-1'-yl)ethanone Fa... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00093400 DAP000942 Approved Drug Nebivolol
CFAMM00093401 CHEMBL208993 Bioactive SureCN14595290
CFAMM00093418 CHEMBL382034 Bioactive SureCN14229649
CFAMM00093407 DNCL003069 Clinical Trial Drug Edivoxetine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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