CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFAD677
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaverine Family
No. of Seeds 53 No. of Other Members 741
Family Centroid CFAMM00094035 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaverine Superfamily
Class Class 24

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Calcium-activated potassium channel subunit alpha-1 Ligand Qui... 3 46
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Acetylcholinesterase Inhibitor Pyridostigmine Family 5 197
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Histamine H1 receptor Ligand Doxylamine Family 2 91
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Histamine H1 receptor Ligand Mepyramine Family 5 65
DNA Binder Elliptinium Acetate Family 11 116
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Citric Acid family 2 58
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Multidrug resistance protein 3 Inhibitor LY335979 Family 1 3
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Neuronal acetylcholine receptor subunit alpha-4 Ligand Isproni... 49 172
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Tivozanib family 4 6
Smoothened homolog Inhibitor LDE225 Family 3 76
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Apricoxib family 8 77
Indeglitazar family 3 39
PF-02545920 family 16 140
8-aminoquinoline Inhibitor Tafenoquine Family 1 0
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Tyrosine kinase Inhibitor PKI166 Family 17 198
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 5
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 3 24
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-m... 2 12
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-hydroxy-5-(2-methyl... 2 1
Metabotropic glutamate receptor 5 Ligand (3-(2-methylquinolin-... 3 6
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Acetylcholinesterase and Cholinesterase Inhibitor 1,4-di(berbe... 5 0
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Sigma non-opioid intracellular receptor 1 and Kappa-type opioi... 3 12
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 5 2
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Platelet-derived growth factor receptor beta and Platelet-deri... 2 19
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
Histamine H1 receptor and Potassium voltage-gated channel subf... 3 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
5-hydroxytryptamine receptor 1A ligand (2S)-1-[(3S,4R)-3-(1,3-... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 6 4
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Cannabinoid receptor 1 ligand AGN-PC-088XYA family 4 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Vascular endothelial growth factor receptor 2 ligand 7-(6-acet... 2 0
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 17
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Ferritin light chain and Ras-related protein Rab-9A inhibitor ... 1 11
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 1
Reverse transcriptase/RNaseH inhibitor AC1MHDM5 family 2 0
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 18
B2 bradykinin receptor ligand SureCN6640854 family 7 4
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 7 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
D(2) dopamine receptor ligand 129722-25-4 family 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Glucocorticoid receptor ligand SureCN4194063 family 1 0
Endothelin-1 receptor ligand SureCN8118632 family 4 5
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Hepatocyte growth factor receptor ligand AGN-PC-08XYVH family 1 1
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Sodium-dependent serotonin transporter inhibitor (4S)-4-[4-[(2... 1 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS94Q ... 6 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Platelet-derived growth factor receptor beta and Macrophage co... 7 0
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Hepatocyte growth factor receptor and Vascular endothelial gro... 14 10
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Hepatocyte growth factor receptor and Vascular endothelial gro... 15 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Corticotropin-releasing factor receptor 1 ligand 8-(2-chloro-4... 13 1
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Beta-secretase 1 inhibitor CHEMBL2152919 family 1 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Beta-secretase 1 inhibitor N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)... 3 5
Transient receptor potential cation channel subfamily V member... 2 4
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Sodium-dependent serotonin transporter and Histamine H3 recept... 6 4
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Hepatocyte growth factor receptor ligand 1-(2-chlorophenyl)-N-... 14 8
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Hepatocyte growth factor receptor ligand 1-[(E)-(2,4-difluorop... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Mitogen-activated protein kinase kinase kinase 11 and Leucine-... 1 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 19 11
Serine/threonine-protein kinase Chk1 inhibitor SureCN4806204 f... 13 7
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Transient receptor potential cation channel subfamily V member... 6 1
Steroid hormone receptor ERR1 and Steroid hormone receptor ERR... 1 4
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[2... 4 4
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854955 f... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
Neuropeptide Y receptor type 5 ligand AGN-PC-040NYD family 3 7
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Renin inhibitor SureCN6043852 family 2 0
Renin inhibitor SureCN6042213 family 2 3
Renin inhibitor SureCN6044003 family 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor N-[4... 1 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 4
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Pol polyprotein inhibitor Tertiary Amide deriv. 58 family 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor AGN-... 1 3
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Glucocorticoid receptor ligand SureCN3894124 family 3 0
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase inhibitor 1-... 1 3
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-(1-methyl-4... 14 12
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(3-ch... 5 4
Sodium-dependent serotonin transporter inhibitor SureCN5878703... 4 5
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
Renin inhibitor SureCN7300793 family 2 5
Lanosterol synthase inhibitor AGN-PC-07BZTX family 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 2
Sodium-dependent serotonin transporter and Alpha-2C adrenergic... 2 2
Platelet-derived growth factor receptor beta and Platelet-deri... 2 2
Sodium/hydrogen exchanger 1 inhibitor 2-[(E)-[7-(2-chloropheny... 2 0
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Nuclear receptor ROR-gamma and Induced myeloid leukemia cell d... 1 1
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 2 10
DNA-dependent protein kinase catalytic subunit inhibitor 2-mor... 1 4
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Transient receptor potential cation channel subfamily V member... 3 2
Farnesyl pyrophosphate synthase inhibitor [phosphono-[[4-(4-pr... 6 0
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 10 10
Vascular endothelial growth factor receptor 2 ligand (4Z)-4-[(... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Glycogen synthase kinase-3 beta and G2/mitotic-specific cyclin... 3 0
Small conductance calcium-activated potassium channel protein ... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 4 3
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 2 2
Orexin receptor type 1 and Orexin receptor type 2 ligand SureC... 1 3
Cytochrome P450 2D6 inhibitor AGN-PC-0509UI family 1 2
Mitogen-activated protein kinase 14 inhibitor Aminopyridine N-... 3 1
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
M-phase inducer phosphatase 2 and Dual specificity protein pho... 1 0
Menin and Histone-lysine N-methyltransferase 2A inhibitor CHEM... 1 0
Beta-lactamase and Muscleblind-like protein 1 inhibitor 2,3-Bi... 1 2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]... 1 0
Acetylcholinesterase and Cholinesterase inhibitor CHEMBL191520... 2 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 0
Protein kinase C theta type inhibitor AGN-PC-04SQV8 family 1 0
Platelet-activating factor receptor ligand AGN-PC-001U4L family 2 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 2 0
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0
8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin-8-one NP 6,7-dime... 47 0
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0
NP (2r,3r,4s,5r)-2-(acetoxymethyl)-6-(quinolin-8-yloxy)tetrahy... 2 1
(E)-3-(2-hydroxyphenyl)-1-pyridin-4-ylprop-2-en-1-one NP (e)-3... 1 0
dimethyl-4-[[4-(2-pyridin-4-ylethyl)piperazin-4-ium-1-yl]methy... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00094035 DAP000959 Approved Drug Papaverine
CFAMM00094295 DNC003813 Investigative Drug 3-Cyclopent-1-enyl-6,7-dimethoxy-quinoline
CFAMM00094086 DNC003787 Investigative Drug 3-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-quinoline
CFAMM00094484 DNC003769 Investigative Drug 6,7-Dimethoxy-3-pyridin-3-yl-quinoline
CFAMM00094108 DNC011112 Investigative Drug 4-[4-(6-methoxynaphthalen-2-yl)benzyl]pyridine
CFAMM00094301 DNC011908 Investigative Drug 6,7-Dimethoxy-4-m-tolyloxy-quinoline
CFAMM00094408 DNC011947 Investigative Drug 6,7-Dimethoxy-4-(3-methoxy-phenoxy)-quinoline
CFAMM00094369 DNC013390 Investigative Drug 7-(3-methoxyphenyl)-2-methyl-1,6-naphthyridine
CFAMM00094031 DNC003804 Investigative Drug 3-(2-Cyclohexyl-ethyl)-6,7-dimethoxy-quinoline
CFAMM00094189 DNC004101 Investigative Drug 5,6,7-Trimethoxy-3-pyridin-4-yl-quinoline
CFAMM00094300 DNC011909 Investigative Drug 3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine
CFAMM00094107 DNC006350 Investigative Drug 3-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine
CFAMM00093727 DNC003902 Investigative Drug 4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline
CFAMM00093810 DNC008928 Investigative Drug 3-(3-Benzyl-6-methoxynaphthalen-2-yl)pyridine
CFAMM00094030 DNC011896 Investigative Drug 6,7-Dimethoxy-4-phenoxy-quinoline
CFAMM00094554 DNC003822 Investigative Drug 6,7-Dimethoxy-3-(2-methoxy-phenyl)-quinoline
CFAMM00094620 DNC003836 Investigative Drug 3-(1H-Indol-3-yl)-6,7-dimethoxy-quinoline
CFAMM00094308 DNC011900 Investigative Drug 6,7-Dimethoxy-4-(2-methoxy-phenoxy)-quinoline
CFAMM00093747 DNC008625 Investigative Drug 4-(6-Methoxynaphthalen-2-yl)isoquinoline
CFAMM00094036 DNC003802 Investigative Drug 3-Cyclopentyl-6,7-dimethoxy-quinoline
CFAMM00094561 DNC003828 Investigative Drug 3-(3,4-Difluoro-phenyl)-6,7-dimethoxy-quinoline
CFAMM00094214 DNC003778 Investigative Drug 6,7-Dimethoxy-3-(4-methoxy-phenyl)-quinoline
CFAMM00094591 DNC003800 Investigative Drug 6,7-Dimethoxy-3-(3-methoxy-phenyl)-quinoline
CFAMM00094553 DNC003823 Investigative Drug 3-Benzyloxy-6,7-dimethoxy-quinoline
CFAMM00094277 DNC003819 Investigative Drug 3-(3-Fluoro-phenyl)-6,7-dimethoxy-quinoline
CFAMM00094382 DNC000303 Investigative Drug Berberine
CFAMM00094029 DNC011897 Investigative Drug 4-(3-Ethoxy-phenoxy)-6,7-dimethoxy-quinoline
CFAMM00094567 DNC011917 Investigative Drug 4-(3-Ethyl-phenoxy)-6,7-dimethoxy-quinoline
CFAMM00093746 DNC008624 Investigative Drug 4-(6-Methoxy-3-methylnaphthalen-2-yl)isoquinoline
CFAMM00094560 DNC003829 Investigative Drug 3-(4-Fluoro-phenyl)-6,7-dimethoxy-quinoline
CFAMM00093897 DNC003839 Investigative Drug 3-Cyclohexylethynyl-6,7-dimethoxy-quinoline
CFAMM00094149 DNC009635 Investigative Drug 3-(2,3-Dihydro-1,4-benzodioxin-6-yl)pyridine
CFAMM00094566 DNC011915 Investigative Drug 6,7-Dimethoxy-4-(4-methoxy-phenoxy)-quinoline
CFAMM00093815 DNC003796 Investigative Drug 6,7-Dimethoxy-3-p-tolyl-quinoline
CFAMM00094345 DNC014493 Investigative Drug pseudocolumbamine trifluoroacetate
CFAMM00094088 DNC003788 Investigative Drug 4-(6,7-Dimethoxy-quinolin-3-yl)-phenol
CFAMM00093745 DNC008623 Investigative Drug 3-(6-Methoxy-3-methylnaphthalen-2-yl)pyridine
CFAMM00094034 DNC003801 Investigative Drug 6,7-Dimethoxy-3-phenylethynyl-quinoline
CFAMM00094403 DNC003665 Investigative Drug CDP840
CFAMM00093794 DNC008081 Investigative Drug JATRORRHIZINE
CFAMM00094043 DNC011935 Investigative Drug 4-(3,5-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline
CFAMM00094565 DNC011913 Investigative Drug 4-(3-Fluoro-phenoxy)-6,7-dimethoxy-quinoline
CFAMM00094253 DNC005715 Investigative Drug 3-(6-methoxynaphthalen-2-yl)pyridine
CFAMM00094344 DNC014495 Investigative Drug pseudopalmatine trifluoroacetate
CFAMM00094191 DNC004104 Investigative Drug 6,7-Dimethoxy-3-pyridin-4-yl-quinoline
CFAMM00093931 DNC003841 Investigative Drug 6,7-Dimethoxy-3-(4-nitro-phenyl)-quinoline
CFAMM00093744 DNC008622 Investigative Drug 3-(6-Methoxynaphthalen-2-yl)-4-methylpyridine
CFAMM00093793 DNC008080 Investigative Drug PALMATINE
CFAMM00094558 DNC003824 Investigative Drug 6,7-Dimethoxy-3-phenyl-quinoline
CFAMM00094033 DNC003806 Investigative Drug 6,7-Dimethoxy-3-((E)-styryl)-quinoline
CFAMM00093837 DNC006344 Investigative Drug 4-(6-methoxy-3,4-dihydronaphthalen-2-yl)pyridine
CFAMM00094042 DNC011934 Investigative Drug 4-(2,3-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline
CFAMM00094343 DNC014494 Investigative Drug palmatine trifluoroacetate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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