CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD684
Family Name Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family
No. of Seeds 7 No. of Other Members 119
Family Centroid CFAMM00094989 Functional Category Approved Drug with Natural Product
Superfamily Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Superfamily
Class Class 528

Cousin Family NamesSeedsMembers
DNA topoisomerase 2-beta and DNA topoisomerase 4 subunit A Inh... 3 40
DNA topoisomerase 2-beta Inhibitor Nalidixic Acid Family 2 5
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Diacylglycerol O-acyltransferase 2 and Hydroxycarboxylic acid ... 4 45
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Aurora kinase A Inhibitor MLN8054 Family 2 5
Dipeptidyl peptidase 4 Inhibitor ABT-279 Family 3 1
Casein kinase II subunit alpha Inhibitor CX-4945 Family 1 7
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 1-methyl-8-(... 1 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 16 34
Type-1 angiotensin II receptor ligand SureCN9527437 family 2 34
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 22
Prostaglandin D2 receptor ligand 2-[3-[6-[2-(2,4-dichloropheny... 7 2
Dipeptidyl peptidase 4 inhibitor 3-[6-[(3R,4S)-3-amino-4-(2,4,... 3 7
Neuropeptide Y receptor type 5 ligand AGN-PC-07R6YQ family 7 7
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-methyl-4... 15 14
Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4... 2 0
B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyan... 8 7
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 2-[3-[... 1 0
Aurora kinase A inhibitor Bisanilinopyrimidine, 6i family 1 0
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
Aurora kinase A inhibitor 4-[[4-(2-chloroanilino)pyrimidin-2-y... 1 0
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(1-propan-2-ylpyr... 5 6
C-C chemokine receptor type 5 ligand 4-[[5-[[4-[(5R)-5-(3-chlo... 1 0
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 1 2
Vascular endothelial growth factor receptor 2 ligand pyrimidin... 2 2
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Type-1 angiotensin II receptor ligand 2-ethyl-4-[[4-[2-(2H-tet... 2 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-071H3F fa... 3 0
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 1 1
Glycogen synthase kinase-3 beta inhibitor 5-amino-1-cyclopropy... 3 14
Adenosine receptor A2a and Adenosine receptor A1 ligand N-benz... 3 12
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-(4-amino-... 2 3
Cyclic AMP-dependent transcription factor ATF-1 and Nuclear fa... 3 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 2
NP Agn-pc-05rdcq Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00094989 DAP000972 Approved Drug Niflumic Acid
CFAMM00095042 CHEMBL2170427 Bioactive Bisanilinopyrimidine, 6a
CFAMM00095032 CHEMBL2170602 Bioactive Bisanilinopyrimidine, 3n
CFAMM00095053 DNC007458 Investigative Drug 2-(2-propoxypyrimidin-4-ylamino)benzoic acid
CFAMM00095052 DNC007454 Investigative Drug 2-(2-(butylamino)pyrimidin-4-ylamino)benzoic acid
CFAMM00095051 DNC007457 Investigative Drug 2-(2-(pentyloxy)pyrimidin-4-ylamino)benzoic acid
CFAMM00095049 DNC007453 Investigative Drug 2-(2-butoxypyrimidin-4-ylamino)benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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