CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD69
Family Name u-type opioid receptor ligand opiate analog Buprenorphine Family
No. of Seeds 78 No. of Other Members 234
Family Centroid CFAMM00015428 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily opioid receptor ligand opiate Codeine Buprenorphine Oxymorphone Superfamily
Class Class 66

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Delta-type opioid receptor ligand opiate analog Codeine Family 15 184
u-type opioid receptor ligand opiate opiate analog Oxymorphone... 22 105
Opioid receptor ligand opiate Levorphanol Family 18 537
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Acetylcholinesterase Inhibitor Galantamine Family 4 49
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Nalfurafine Hcl family 33 107
D(3) dopamine receptor Ligand U-99194A Family 7 33
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Peptide deformylase, mitochondrial Inhibitor Tylophorinidine F... 7 1
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 18 25
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 32 30
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-br... 2 1
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Delta-type opioid receptor Ligand 6-cinnamoyl-n-methylstephasu... 3 0
Delta-type opioid receptor Ligand Longanine Family 3 0
Mu-type opioid receptor Ligand Cyprodime Family 12 8
D(1A) dopamine receptor Ligand SCH-12679 Family 1 0
Tubulin beta chain Inhibitor Colchinol Family 3 109
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 6 1
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 16 10
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 3 1
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 20 0
5-hydroxytryptamine receptor 1A ligand SureCN7035190 family 10 17
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Mu-type opioid receptor ligand Morphine-6-glucuronide family 7 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 6 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 18 1
Delta-type opioid receptor and Kappa-type opioid receptor liga... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 6 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 9 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 6 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 7 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 9 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 6 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 6 3
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Delta-type opioid receptor and Kappa-type opioid receptor liga... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 0
Mu-type opioid receptor and Gastrin/cholecystokinin type B rec... 1 0
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00015637 DAP000380 Approved Drug Nalbuphine
CFAMM00015628 DAP001407 Approved Drug Nalmefene
CFAMM00015404 DAP001353 Approved Drug Buprenex
CFAMM00015428 DAP000073 Approved Drug Buprenorphine
CFAMM00015732 CHEMBL2338719 Bioactive CHEMBL2338719
CFAMM00015646 CHEMBL175344 Bioactive (12bS)-3-methylspiro[2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,2'-oxirane]-4a,9-diol
CFAMM00015661 CHEMBL353979 Bioactive AC1NBCLQ
CFAMM00015586 CHEMBL2113670 Bioactive CHEMBL2113670
CFAMM00015441 CHEMBL2338724 Bioactive CHEMBL2338724
CFAMM00015579 CHEMBL2338745 Bioactive CHEMBL2338745
CFAMM00015563 CHEMBL2338739 Bioactive CHEMBL2338739
CFAMM00015731 CHEMBL2338718 Bioactive CHEMBL2338718
CFAMM00015484 CHEMBL1908334 Bioactive Propylorvinol
CFAMM00015406 CHEMBL281986 Bioactive CHEMBL281986
CFAMM00015688 CHEMBL2338756 Bioactive CHEMBL2338756
CFAMM00015562 CHEMBL2338738 Bioactive CHEMBL2338738
CFAMM00015440 CHEMBL2338725 Bioactive CHEMBL2338725
CFAMM00015730 CHEMBL2338741 Bioactive CHEMBL2338741
CFAMM00015584 CHEMBL2338742 Bioactive CHEMBL2338742
CFAMM00015672 CHEMBL1834409 Bioactive CHEMBL1834409
CFAMM00015499 CHEMBL578629 Bioactive CHEMBL578629
CFAMM00015561 CHEMBL2338737 Bioactive CHEMBL2338737
CFAMM00015439 CHEMBL2338726 Bioactive CHEMBL2338726
CFAMM00015736 CHEMBL2338714 Bioactive ISOPENTYL ORVINOL M320
CFAMM00015445 CHEMBL2338720 Bioactive CHEMBL2338720
CFAMM00015583 CHEMBL2338743 Bioactive CHEMBL2338743
CFAMM00015643 CHEMBL2338735 Bioactive CHEMBL2338735
CFAMM00015700 CHEMBL349841 Bioactive CHEMBL349841
CFAMM00015560 CHEMBL2338736 Bioactive CHEMBL2338736
CFAMM00015438 CHEMBL2338727 Bioactive CHEMBL2338727
CFAMM00015452 CHEMBL416765 Bioactive CHEMBL416765
CFAMM00015474 CHEMBL611128 Bioactive (4R,12bS)-3-(cyclopropylmethyl)spiro[2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,2'-oxirane]-4a,9-diol
CFAMM00015735 CHEMBL2338717 Bioactive CHEMBL2338717
CFAMM00015491 CHEMBL2311186 Bioactive [3H]-diprenorphine
CFAMM00015444 CHEMBL2338721 Bioactive CHEMBL2338721
CFAMM00015582 CHEMBL2338740 Bioactive CHEMBL2338740
CFAMM00015559 CHEMBL2338731 Bioactive CHEMBL2338731
CFAMM00015450 CHEMBL2338728 Bioactive CHEMBL2338728
CFAMM00015734 CHEMBL2338716 Bioactive CHEMBL2338716
CFAMM00015691 CHEMBL2338755 Bioactive CHEMBL2338755
CFAMM00015443 CHEMBL2338722 Bioactive CHEMBL2338722
CFAMM00015462 CHEMBL281786 Bioactive DEA No. 9058
CFAMM00015496 CHEMBL169552 Bioactive CHEMBL169552
CFAMM00015647 CHEMBL2368861 Bioactive NIH-8805
CFAMM00015449 CHEMBL2338729 Bioactive CHEMBL2338729
CFAMM00015754 CHEMBL355296 Bioactive CHEMBL355296
CFAMM00015558 CHEMBL2338730 Bioactive CHEMBL2338730
CFAMM00015587 CHEMBL2113672 Bioactive CHEMBL2113672
CFAMM00015690 CHEMBL2338754 Bioactive CHEMBL2338754
CFAMM00015639 CHEMBL1169585 Bioactive CHEMBL1169585
CFAMM00015442 CHEMBL2338723 Bioactive CHEMBL2338723
CFAMM00015580 CHEMBL2338744 Bioactive CHEMBL2338744
CFAMM00015485 DNCL003033 Clinical Trial Drug ALKS5461
CFAMM00015398 DNCL003360 Clinical Trial Drug Naloxegol
CFAMM00015447 DNC003299 Investigative Drug Dihydromorphine
CFAMM00015578 DNC013079 Investigative Drug DM6S
CFAMM00015694 DNC008752 Investigative Drug Naltrexone-6-alpha-ol
CFAMM00015446 DNC003298 Investigative Drug Etorphine
CFAMM00015530 DNC009906 Investigative Drug 6beta-naltrexol HCl
CFAMM00015644 DNC000631 Investigative Drug Etorphine
CFAMM00015506 DNC002867 Investigative Drug Diprenorphine
CFAMM00015693 DNC008751 Investigative Drug Naltrexone-6-beta-ol
CFAMM00015410 DNC009077 Investigative Drug 6-desoxonaltrexone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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