CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD690
Family Name D(2) dopamine receptor ligand diphenylbutylpiperidine derivative Fluspirilene Family
No. of Seeds 43 No. of Other Members 161
Family Centroid CFAMM00095391 Functional Category Approved Drug with Natural Product
Superfamily dopamine receptor ligand diphenylbutylpiperidine derivative Pimozide Fluspirilene Superfamily
Class Class 220

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Mu-type opioid receptor ligand opiate Remifentanil Family 10 24
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
K-604 family 4 71
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Nociceptin receptor Ligand J-113397 Family 3 14
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 9 19
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
Cannabinoid receptor 1 Ligand 1-[bis(4-iodophenyl)methyl]-3-(4... 4 13
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 3 3
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 2 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
B2 bradykinin receptor ligand AGN-PC-074WA4 family 2 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 1
Calcitonin gene-related peptide type 1 receptor ligand N,N-dim... 12 32
Cannabinoid receptor 2 ligand SureCN738026 family 5 68
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 5 14
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 6
Disintegrin and metalloproteinase domain-containing protein 17... 1 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Calcitonin gene-related peptide type 1 receptor and Dual speci... 8 4
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Cathepsin K and Cathepsin L1 inhibitor 1-[(2S)-1-[[cyano(methy... 2 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 3
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 0
C-C chemokine receptor type 3 ligand 4-(5-amino-2-oxo-3H-benzi... 1 0
C-C chemokine receptor type 3 ligand (2S)-1-N-[(1R,5R)-8-[(6-f... 1 1
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN13655018... 6 23
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 2
Melanin-concentrating hormone receptor 1 ligand 3-chloro-5-[4-... 2 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 3 1
Phospholipase D1 and Phospholipase D2 inhibitor 4-bromo-N-[(2S... 1 2
Translocator protein inhibitor CHEMBL2332254 family 6 1
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Receptor activity-modifying protein 1 and Calcitonin gene-rela... 2 4
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Dipeptidyl peptidase 4 inhibitor 4-[4-[(3S,5S)-5-(1,3-thiazoli... 3 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Histamine H3 receptor and Histamine receptor H3 ligand N-[4-[3... 5 1
Histamine H3 receptor and Histamine receptor H3 ligand 1-cyclo... 3 4
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 4 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Mu-type opioid receptor and Nociceptin receptor ligand SureCN8... 7 1
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
C-C chemokine receptor type 3 ligand AGN-PC-073RIP family 2 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Capsid scaffolding protein inhibitor AC1LAC5B family 1 39
Dipeptidyl peptidase 4 inhibitor 4-[[(3S,5S)-5-[(2S)-2-cyanopy... 4 12
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
C-C chemokine receptor type 5 ligand AC1L9YPM family 3 6
Nociceptin receptor and Mu-type opioid receptor ligand spiropi... 1 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 4 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRYI family 2 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 3 5
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 5
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Coagulation factor VII and Prothrombin inhibitor 2-[(4-carbami... 2 1
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Sodium- and chloride-dependent glycine transporter 1 and Mu-ty... 2 6
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 7 1
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4
Aldose reductase inhibitor Spiro-cimqat family 6 8
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quin... 4 16
Aldose reductase inhibitor SureCN10775957 family 2 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 1 0
Substance-P receptor ligand (2S)-2-N-[2-[(3,5-dimethylphenyl)m... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00095391 DAP000980 Approved Drug Fluspirilene
CFAMM00095251 CHEMBL28172 Bioactive SureCN6840984
CFAMM00095294 CHEMBL474092 Bioactive AGN-PC-04XL9G
CFAMM00095404 CHEMBL241087 Bioactive 8-(6-fluoro-4,4-dimethyl-2,3-dihydro-1H-naphthalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
CFAMM00095323 CHEMBL514489 Bioactive AGN-PC-04XL9B
CFAMM00095451 CHEMBL439212 Bioactive 8-[bis(2-methylphenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
CFAMM00095273 CHEMBL281274 Bioactive AGN-PC-00PHS8
CFAMM00095344 CHEMBL354065 Bioactive AGN-PC-02BW9B
CFAMM00095411 CHEMBL474687 Bioactive AGN-PC-04XL9A
CFAMM00095418 CHEMBL280827 Bioactive SureCN8088157
CFAMM00095365 CHEMBL169947 Bioactive SureCN6839215
CFAMM00095379 CHEMBL166387 Bioactive SureCN5108012
CFAMM00095262 CHEMBL284414 Bioactive AGN-PC-09Z4CJ
CFAMM00095329 CHEMBL436243 Bioactive AGN-PC-00P62Q
CFAMM00095426 CHEMBL27716 Bioactive SureCN8079716
CFAMM00095292 CHEMBL474096 Bioactive AGN-PC-04XL9L
CFAMM00095456 CHEMBL515575 Bioactive AGN-PC-04XL9M
CFAMM00095255 CHEMBL473272 Bioactive AGN-PC-04XL9E
CFAMM00095409 CHEMBL511162 Bioactive AGN-PC-04XL9P
CFAMM00095342 CHEMBL355202 Bioactive SureCN6838730
CFAMM00095277 CHEMBL239822 Bioactive spiropiperidine analogue, 3
CFAMM00095254 CHEMBL473279 Bioactive AGN-PC-04XL9I
CFAMM00095401 CHEMBL383539 Bioactive SureCN1689584
CFAMM00095362 CHEMBL26999 Bioactive 1-phenyl-8-(1,2,3,4-tetrahydronaphthalen-2-yl)-1,3,8-triazaspiro[4.5]decan-4-one
CFAMM00095447 CHEMBL166445 Bioactive AGN-PC-00KC3E
CFAMM00095408 CHEMBL354291 Bioactive SureCN6839338
CFAMM00095422 CHEMBL471882 Bioactive AGN-PC-04XL9O
CFAMM00095253 CHEMBL473278 Bioactive AGN-PC-04XL9H
CFAMM00095283 CHEMBL474485 Bioactive spiropiperidine analogue, 54
CFAMM00095361 CHEMBL27460 Bioactive SureCN6834468
CFAMM00095398 CHEMBL475094 Bioactive AGN-PC-04XL9F
CFAMM00095406 DCL000176 Clinical Trial Drug ND1251
CFAMM00095380 DNC001227 Investigative Drug Ro-64-6198

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27255 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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