CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Glucocorticoid receptor ligand glucocorticoid analog Dexamethasone Family
No. of Seeds 13 No. of Other Members 248
Family Centroid CFAMM00001210 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Glucocorticoid receptor, Corticosteroid-binding globulin, Phospholipase A2 binding glucocorticoid, corticosteroid, Propionate Superfamily
Class Class 7

Cousin Family NamesSeedsMembers
Glucocorticoid receptor ligand glucocorticoid analog Flunisol... 10 41
Corticosteroid-binding globulin inhibitor corticosteroid analo... 6 10
Corticosteroid-binding globulin Inhibitor Rimexolone Family 6 138
Corticosteroid-binding globulin inhibitor corticosteroid analo... 11 112
Androgen receptor ligand anabolic androgenic steroid Testoster... 8 198
Progesterone receptor ligand steroidal progestin Etonogestrel ... 8 31
Progesterone receptor ligand steroidal progestin Medroxyproges... 6 20
Elongation factor G Inhibitor Fusidic Acid Family 3 34
Glucocorticoid receptor Ligand Fluticasone Propionate Family 3 5
Glucocorticoid receptor ligand corticosteroid Prednisone Family 2 1
Phospholipase A2 Inhibitor Halobetasol Propionate Family 3 5
Mineralocorticoid receptor ligand steroid progestogen analog D... 3 240
Phospholipase A2 Inhibitor Hydrocortamate Family 1 0
Hydroxyprogesterone family 4 37
Trimegestone family 7 25
HE3286 family 5 34
Aminopeptidase N Inhibitor [(125)i] RB129 Family 11 204
Nuclear receptor subfamily 1 group I member 2 Ligand Pregnenol... 1 1
DNA polymerase and Glycogen phosphorylase, muscle form Inhibit... 32 22
Prostaglandin G/H synthase 2 Inhibitor 8alpha,19-dihydroxylabd... 2 10
Aromatase inhibitor (10R,13S)-13-methyl-10-(oxiran-2-yl)-2,6,7... 1 0
Prothrombin and Trypsin-1 inhibitor CHEMBL457155 family 1 12
Glucocorticoid receptor and Interstitial collagenase ligand Su... 12 11
Ecdysone receptor ligand Ponasterone A family 1 22
Potassium-transporting ATPase alpha chain 2 and Sodium/potassi... 1 0
Steroid 17-alpha-hydroxylase/17,20 lyase inhibitor CHEMBL21127... 1 7
Integrin alpha-L inhibitor Cucurbitacin E family 1 0
Glucocorticoid receptor ligand (9R,10S,11S,13S,16R,17R)-9-fluo... 1 6
Prostaglandin G/H synthase 2 inhibitor bruguierins A family 1 4
Steroids and Steroid Derivatives Metabolite 14alpha-Hydroxyixo... 1 4
Prenol Lipids Metabolite Ineketone Family 1 0


External ID

Functional Category

Molecule Name

CFAMM00001128 DAP000422 Approved Drug Paramethasone
CFAMM00001211 DAP000417 Approved Drug Triamcinolone
CFAMM00001210 DAP000007 Approved Drug Dexamethasone
CFAMM00000723 DNAP001642 Approved Drug Betamethasone dipropionate
CFAMM00000853 DAP001047 Approved Drug Fluorometholone
CFAMM00000852 DAP001043 Approved Drug Betamethasone
CFAMM00001213 DAP000419 Approved Drug Prednisolone
CFAMM00001145 DAP001184 Approved Drug Diflorasone
CFAMM00000926 DAP000718 Approved Drug Hydrocortisone
CFAMM00000851 DAP001040 Approved Drug Methylprednisolone
CFAMM00000755 DAP001105 Approved Drug Fludrocortisone
CFAMM00000804 CHEMBL1201392 Bioactive flumethasone
CFAMM00000748 CHEMBL1940557 Bioactive (8S,9S,10R,11S,13S,14S,16R,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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