CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD729
Family Name Histamine H1 receptor Ligand Pheniramine Family
No. of Seeds 10 No. of Other Members 380
Family Centroid CFAMM00099058 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Histamine H1 receptor ligand Pheniramine Triprolidine, Nicotinic acetylcholine receptor ligand Nicotine Superfamily
Class Class 141

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Farnesyl pyrophosphate synthase Inhibitor Risedronate Family 4 28
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Prothrombin Inhibitor Ximelegatran Family 8 157
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
Transient receptor potential cation channel subfamily V member... 15 158
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
Transient receptor potential cation channel subfamily V member... 15 457
Proteinase-activated receptor 1 Ligand SCH-530348 Family 20 215
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Substance-P receptor Ligand TAK-637 Family 18 63
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 23 63
Amg 423 family 7 47
ABC294640 family 5 75
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor Cycl... 1 0
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
MO15-related protein kinase Pfmrk Inhibitor (e)-1-(4-nitro-phe... 2 9
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Cytochrome P450 11B1, mitochondrial Inhibitor 3-(6-bromo-napht... 1 1
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Farnesyl pyrophosphate synthase Inhibitor Piridronic Acid Family 3 14
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Cathepsin S Inhibitor 6-(3-(trifluoromethyl)phenyl)picolinonit... 7 2
Cathepsin L1 Inhibitor (3-bromobenzoylpyridine)thiosemicarbazo... 1 0
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Reverse transcriptase Inhibitor PT-102 Family 8 12
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Translocator protein Inhibitor 5-phenyl-6-thia-10b-aza-benzo[e... 1 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 3
Histamine H1 receptor and Potassium voltage-gated channel subf... 5 5
Metabotropic glutamate receptor 5 ligand [18F]FDEGPECO family 5 2
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YYL... 1 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
Metabotropic glutamate receptor 5 ligand [(E)-(1,2-dicyclohexy... 1 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
Sodium-dependent serotonin transporter inhibitor SureCN6087152... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 3 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 8 6
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SQ6 family 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Geranylgeranyl pyrophosphate synthase and Farnesyl pyrophospha... 1 0
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Glucocorticoid receptor ligand 1,1,1-trifluoro-2-[(1-methyl-3,... 3 4
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 4
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Prostaglandin D2 receptor 2 ligand SureCN317401 family 3 8
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... 1 0
Neuronal acetylcholine receptor subunit alpha-6 ligand AGN-PC-... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 3 0
G-protein coupled bile acid receptor 1 ligand 1-[4-[(1R,3E)-1-... 1 1
D(4) dopamine receptor and D(3) dopamine receptor ligand 1-(2,... 1 0
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 1
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
D(3) dopamine receptor and D(4) dopamine receptor ligand (7S)-... 1 2
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 2 0
5-hydroxytryptamine receptor 7 ligand 6-bromo-1-[2-[4-(cyclopr... 2 4
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Histamine H3 receptor ligand AGN-PC-09M6FC family 1 9
Squalene synthase inhibitor AGN-PC-00ONKT family 1 0
Beta-secretase 2 and Beta-secretase 1 inhibitor 2-cyclopropyl-... 1 1
Glucose-dependent insulinotropic receptor ligand tert-butyl 4-... 2 1
TGF-beta receptor type-1 ligand 6-bromo-4-(2-(6-methylpyridin-... 1 3
Cytochrome P450 2C19 inhibitor CHEMBL1449918 family 1 0
Tyrosyl-DNA phosphodiesterase 1 and Inositol monophosphatase 1... 1 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Farnesyl pyrophosphate synthase inhibitor [[(5-benzylpyridin-3... 1 0
Potassium voltage-gated channel subfamily A member 5 and Inter... 2 0
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 1 0
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1
Neuronal acetylcholine receptor subunit alpha-3 and Neuronal a... 1 5
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
Pyridines and Derivatives Metabolite (S)-Actinidine Family 1 0
Pyridines and Derivatives Metabolite Rotundine A Family 1 0
NP 3-((1-(3-(2-(pyridin-3-yl)piperidin-1-yl)prop-1-yn-1-yl)cyc... 12 0
Putative NP ZINC38570085 Family 14 0
1,5-dioxidopyrrolo[3,2-c]pyridin-5-ium NP Agn-pc-0639xa Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00099058 DAP001063 Approved Drug Pheniramine
CFAMM00099056 DAP001066 Approved Drug Brompheniramine
CFAMM00099071 DAP001366 Approved Drug Dimethindene
CFAMM00099061 DAP001068 Approved Drug Dexbrompheniramine
CFAMM00098733 DAP001079 Approved Drug Azatadine
CFAMM00098814 CHEMBL147135 Bioactive 2,4-Bis(benzyl)pyridine
CFAMM00099016 CHEMBL855 Bioactive triprolidine
CFAMM00098765 DNC009877 Investigative Drug R-dimethindene

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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