CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Alpha adrenergic receptor ligand ergot alkaloid Dihydroergotamine Family
No. of Seeds 7 No. of Other Members 12
Family Centroid CFAMM00016056 Functional Category Approved Drug with Human Metabolite
Superfamily biogenic amine receptor binding ergot alkaloid Superfamily
Class Class 71

Cousin Family NamesSeedsMembers
Alpha-1 adrenergic receptor ligand ergot alkaloid Ergotamine F... 1 0
HIV protease Inhibitor Indinavir Family 36 211
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor Ligand Bromocriptine Family 2 0
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Histone deacetylase Inhibitor ST-5732 Family 8 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1


External ID

Functional Category

Molecule Name

CFAMM00016030 DAP000852 Approved Drug Dihydroergotoxine
CFAMM00016048 DAP000901 Approved Drug Ergoloid mesylate
CFAMM00016056 DAP000078 Approved Drug Dihydroergotamine
CFAMM00016054 CHEMBL1385840 Bioactive Ergocornine
CFAMM00016028 CHEMBL18329 Bioactive Alpha-Ergocryptine
CFAMM00016033 CHEMBL442 Bioactive ERGOTAMINE

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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