CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD732
Family Name Histamine H1 receptor Ligand Emedastine Family
No. of Seeds 5 No. of Other Members 115
Family Centroid CFAMM00099586 Functional Category Approved Drug with Natural Product
Superfamily Histamine H1 receptor Ligand Emedastine Superfamily
Class Class 561

Cousin Family NamesSeedsMembers
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
HCV NS4B protein Inhibitor Clemizole Family 2 43
Tryptase Inhibitor Babim Family 12 90
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Farnesyl pyrophosphate synthase Inhibitor [2-(benzoimidazol-1-... 2 16
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Cytochrome P450 11B1, mitochondrial Inhibitor 3-(1-benzyl-1h-i... 3 5
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
cGMP-specific 3',5'-cyclic phosphodiesterase and Potassium vol... 13 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN5... 6 24
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 7
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
Sorbitol dehydrogenase inhibitor SureCN6335187 family 2 6
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
Cellular tumor antigen p53 and Thyrotropin receptor ligand CHE... 1 5
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 5 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Histamine H1 receptor and Potassium voltage-gated channel subf... 1 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
C-C chemokine receptor type 3 ligand 5-fluoro-1-[1-[3-(4-fluor... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 11 5
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Survival motor neuron protein and 15-hydroxyprostaglandin dehy... 1 1
Pyruvate kinase PKM inhibitor 2-(benzimidazol-1-ylmethyl)-6-me... 1 0
D(2) dopamine receptor and D(4) dopamine receptor ligand 3-[1-... 1 0
Extracellular calcium-sensing receptor ligand AGN-PC-00FWSJ fa... 1 0
Muscleblind-like protein 1 and Ras-related protein Rab-9A inhi... 1 0
Substance-P receptor ligand 2-[1-ethyl-2-[(E,3Z)-3-(1,3,3-trim... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00099586 DAP001067 Approved Drug Emedastine
CFAMM00099552 CHEMBL18123 Bioactive AGN-PC-00NBSJ
CFAMM00099664 CHEMBL430338 Bioactive AC1MIJLQ
CFAMM00099614 CHEMBL273315 Bioactive AGN-PC-00NBT3
CFAMM00099526 DNC002374 Investigative Drug ZSTK474

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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