CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD733
Family Name Histamine H1 receptor ligand diphenylpiperidine analog Diphenylpyraline Family
No. of Seeds 13 No. of Other Members 224
Family Centroid CFAMM00099711 Functional Category Approved Drug with Human Metabolite
Superfamily Biogenic amine receptor Diphenhydramine Phendimetrazine Diphenylpyraline Superfamily
Class Class 231

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Histamine H1 receptor Ligand Terfenadine Family 3 50
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Citalopram Family 6 4
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
D(2) dopamine receptor Ligand Haloperidol Family 5 53
Histamine H1 receptor Ligand Clemastine Family 5 76
Muscarinic acetylcholine receptor Ligand Flutropium Bromide Fa... 6 45
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Histamine H1 receptor Ligand Diphenhydramine Family 5 75
Sodium channel protein type 5 subunit alpha Ligand Hexylcaine ... 4 94
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Cocain... 13 136
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Histamine H1 receptor Ligand Chlophedianol Family 4 46
Muscarinic acetylcholine receptor Ligand Mepenzolate Family 35 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Mu-type opioid receptor ligand opiate Methadyl Acetate Family 5 9
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Pitolisant family 4 24
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
Peptide deformylase, mitochondrial Inhibitor Hydroxamates Family 6 17
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Adenosine receptor A3 and D(2) dopamine receptor Ligand (+)-bu... 5 14
Substance-P receptor Ligand L-733060 Family 19 71
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Substance-P receptor Ligand SCH-388714 Family 26 8
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Sodium-dependent noradrenaline transporter Inhibitor (r)-1-((s... 3 8
Cholinesterase Inhibitor 4-[4-(benzyloxy)piperidino]butyl-3-fl... 5 18
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 5 14
Potassium voltage-gated channel subfamily H member 2 Ligand [1... 2 23
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-ri... 5 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 19
Glutamate receptor ionotropic, NMDA 3A and Glutamate receptor ... 2 1
Substance-P receptor ligand (1S,2R)-2-[(1R)-1-[3,5-bis(trifluo... 12 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand Sur... 6 53
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 11
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 1 2
Sigma non-opioid intracellular receptor 1 ligand (1R)-1'-benzy... 7 27
Sigma non-opioid intracellular receptor 1 ligand 2-[(3R)-1'-(c... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-076TWX... 8 5
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 3 27
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 1
Substance-P receptor ligand (2S)-3-[[3,5-bis(trifluoromethyl)p... 1 4
Vesicular acetylcholine transporter inhibitor BENZOVESAMICOL f... 7 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 18
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 1 1
Substance-P receptor ligand 1-[4-[[3,5-bis(trifluoromethyl)phe... 5 8
Substance-P receptor ligand SureCN8112982 family 1 0
Substance-P receptor ligand 4-[[3,5-bis(trifluoromethyl)phenyl... 2 1
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Sigma non-opioid intracellular receptor 1 ligand SureCN5315520... 3 11
Sigma non-opioid intracellular receptor 1 ligand N-benzyl-2-[(... 1 5
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-methoxy-1-[(2S)-... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 3
Muscarinic acetylcholine receptor M3 ligand 3-[8-methyl-8-(2-p... 3 0
Vesicular acetylcholine transporter inhibitor 2-Naphthalenol, ... 3 2
Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Substance-P receptor ligand AGN-PC-03NGZP family 3 0
Substance-P receptor ligand (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trif... 8 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 1
Sodium-dependent serotonin transporter and Substance-P recepto... 2 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 1 0
Substance-P receptor and Sodium-dependent serotonin transporte... 6 1
Substance-P receptor ligand 1-[(3S,4R)-3-[(1R)-1-[3,5-bis(trif... 9 0
Substance-P receptor ligand (5S)-5-[(3S,4R)-3-[(1R)-1-[3,5-bis... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Substance-P receptor ligand SureCN8415737 family 3 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7425449... 2 0
Substance-P receptor ligand methyl 2-[(2S,3S)-2-[[3,5-bis(trif... 1 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 12
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0
Vesicular acetylcholine transporter inhibitor (1R,2R)-2-spiro[... 3 2
Squalene synthase inhibitor 3-[2-(4-phenylphenyl)ethynyl]-1-az... 2 1
C-C chemokine receptor type 5 ligand AC1LAKN8 family 4 5
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Substance-P receptor ligand AGN-PC-02K8GG family 1 1
Sodium-dependent dopamine transporter and Sigma non-opioid int... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Cathepsin B and Cathepsin S inhibitor (4S,5R)-4-phenylmethoxy-... 1 7
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Substance-P receptor ligand SureCN8912140 family 2 12
Cannabinoid receptor 2 ligand SureCN4472215 family 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0793IB... 2 0
Substance-P receptor ligand (3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-bis... 4 0
Substance-P receptor and Voltage-dependent L-type calcium chan... 1 0
Histamine H1 receptor and 5-hydroxytryptamine receptor 2A liga... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 1
Sigma non-opioid intracellular receptor 1 and Kappa-type opioi... 2 1
Cathepsin K and Cathepsin L1 inhibitor 3-(phenylmethoxymethyl)... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 5
Membrane primary amine oxidase and Amine oxidase [flavin-conta... 2 0
Voltage-dependent N-type calcium channel subunit alpha-1B and ... 1 3
Dibenzocycloheptenes Metabolite E-10-Hydroxynortriptyline Family 1 0
7-phenyl-1,3-diazaadamantan-6-ol NP ZINC32124180 Family 5 0
Putative NP ZINC55525127 Family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00099820 DAP001121 Approved Drug Benztropine
CFAMM00099711 DAP001071 Approved Drug Diphenylpyraline
CFAMM00099777 DNC013128 Investigative Drug 10S-hydroxylobelane
CFAMM00099857 DNC013133 Investigative Drug 8S-hydroxylobel-9-ene
CFAMM00099776 DNC013129 Investigative Drug 8S-hydroxylobelane
CFAMM00099856 DNC013132 Investigative Drug 10S-hydroxylobel-7-ene
CFAMM00099745 DNC007501 Investigative Drug 1-benzhydryl-4-phenyl-4-propoxypiperidine
CFAMM00099813 DNC005986 Investigative Drug DIFLUOROBENZTROPINE
CFAMM00099775 DNC013127 Investigative Drug 10R-hydroxylobelane
CFAMM00099855 DNC013131 Investigative Drug 10R-hydroxylobel-7-ene
CFAMM00099854 DNC013130 Investigative Drug 8R-hydroxylobelane
CFAMM00099852 DNC013134 Investigative Drug 8R-hydroxylobel-9-ene
CFAMM00099913 DNC007502 Investigative Drug 1-benzhydryl-4-ethoxy-4-phenylpiperidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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