CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Histamine H1 receptor ligand phenothiazine derivative Mequitazine Family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00099974 Functional Category Approved Drug
Superfamily Biogenic amine receptor, Calmodulin binding phenothiazine Superfamily
Class Class 32

Cousin Family NamesSeedsMembers
Calmodulin inhibitor phenothiazine derivative Trifluoperazine ... 3 30
D(2) dopamine receptor Ligand phenothiazine analog Prochlorper... 4 25
Alpha adrenergic receptor ligand phenothiazine derivative Thio... 4 10
Muscarinic acetylcholine receptor M5 ligand phenothiazine deri... 8 37
Alpha-1B adrenergic receptor Ligand Propericiazine Family 2 0
Mannose-6-phosphate isomerase Inhibitor Sulfoxone Family 3 20
5-hydroxytryptamine receptor Ligand Lu AA21004 Family 13 39
5-hydroxytryptamine receptor 6 Ligand 4-(4-benzenesulfonamidop... 4 5
Cholinesterase Inhibitor 1,2-di(10h-phenothiazin-10-yl)ethane-... 1 0
Cholinesterase Inhibitor Butyl 10h-phenothiazine-10-carboxylat... 4 3
Cholinesterase Inhibitor N-cyclohexyl-1'h-phenothiazine-1'-car... 7 2
Cholinesterase Inhibitor Morpholino(1'h-phenothiazin-1'-yl)met... 2 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 6 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 18 12
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sigma non-opioid intracellular receptor 1 ligand 3-[4-(azepan-... 8 1
Cholinesterase inhibitor 11-[[(1R,9aR)-2,3,4,6,7,8,9,9a-octahy... 1 0


External ID

Functional Category

Molecule Name

CFAMM00099974 DAP001078 Approved Drug Mequitazine
CFAMM00099971 CHEMBL366732 Bioactive AGN-PC-00KGZJ

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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