CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD738
Family Name Histone deacetylase 1 Inhibitor Vorinostat Family
No. of Seeds 26 No. of Other Members 138
Family Centroid CFAMM00100115 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Histone deacetylase 1 Inhibitor Vorinostat Superfamily
Class Class 564

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Androgen receptor ligand aniline derivative Flutamide Family 3 9
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Cholesterol side-chain cleavage enzyme, mitochondrial and Arom... 9 26
Mannose-6-phosphate isomerase Inhibitor Sulfacetamide Family 19 117
Serum albumin Inhibitor Ebselen Family 3 62
3-hydroxy-3-methylglutaryl-coenzyme A reductase Inhibitor Simv... 4 27
Dual specificity mitogen-activated protein kinase kinase Inhib... 5 13
Motilin receptor Ligand GSK962040 Family 30 457
Poly [ADP-ribose] polymerase 1 Inhibitor BSI-201 Family 3 16
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-h... 3 16
Proto-oncogene tyrosine-protein kinase Src Inhibitor ISO24 Family 3 9
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor N-(4-s... 12 92
Tyrosine-protein phosphatase non-receptor type 1 Ligand [[4-(a... 1 7
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 6-(2... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Histone Deacetylase 8 Inhibitor 6-(2-mercaptoacetamido)-n-phen... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-morp... 6 81
Poly [ADP-ribose] polymerase 1 Inhibitor 8-amino-6h,11h-indeno... 3 9
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Transient receptor potential cation channel subfamily V member... 6 33
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Dual specificity mitogen-activated protein kinase kinase 1 Inh... 1 1
Androgen receptor Ligand 6-n-propyl -4-trifluoromethylquinolin... 29 13
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 1 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Transient receptor potential cation channel subfamily V member... 1 5
Progesterone receptor Ligand 3-(3,3-dimethyl-2-oxoindolin-5-yl... 2 10
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmaleimid... 2 11
Sphingosine kinase 2 Inhibitor (r)-2-amino-4-hydroxy-n-(4-octy... 3 9
Neutrophil elastase Inhibitor 3-butyl-3-ethyl-1-phenylazetidin... 6 5
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 9h-bet... 1 1
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 8 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Tyrosinase Inhibitor S-2-(o-toluidino)-2-oxoethyl Carbamothioa... 1 1
Histone Deacetylase 8 Inhibitor S-2,9-dioxo-9-(phenylamino)non... 1 0
Tyrosinase Inhibitor 1-hydroxy-3-phenylurea Family 2 10
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
DNA topoisomerase Inhibitor 6-p-tolylamino-1h-pyrimidine-2,4-d... 3 17
DNA topoisomerase Inhibitor 6-(naphthalen-2-ylamino)-1h-pyrimi... 2 1
Myeloperoxidase Inhibitor 4-aminobenzoic Acid Hydrazide Family 1 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Mitogen-activated protein kinase 1 and M17 leucyl aminopeptida... 1 21
Dihydroorotate dehydrogenase (quinone), mitochondrial and Dihy... 1 2
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Peptide deformylase inhibitor (2R)-2-[[formyl(hydroxy)amino]me... 2 1
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 1
Cathepsin K and Cathepsin L1 inhibitor 1-[(2S)-1-[[cyano(methy... 2 1
Ribosyldihydronicotinamide dehydrogenase [quinone] and Melaton... 1 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Ectonucleotide pyrophosphatase/phosphodiesterase family member... 1 0
Transient receptor potential cation channel subfamily V member... 1 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 3
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Histamine receptor H3 ligand N-[2-methyl-4-[(3S)-3-[(2S)-2-met... 10 7
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
Peptide deformylase inhibitor AGN-PC-073KFH family 6 8
Acetylcholinesterase inhibitor tmtfa family 1 2
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Fatty-acid amide hydrolase 1 inhibitor [(E)-1-[3-(3-carbamoylp... 1 0
Retinal dehydrogenase 1 and Nuclear receptor ROR-gamma ligand ... 3 13
Peptide deformylase inhibitor N-[(2R,4S)-2-butyl-5-methyl-3-ox... 2 0
Cathepsin K inhibitor AGN-PC-075F1H family 2 0
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 2 2
Histone deacetylase 6 and Histone deacetylase 10 inhibitor AGN... 1 0
Aminopeptidase N inhibitor (2S)-2-[(2-chlorophenyl)carbamoylam... 1 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
P2X purinoceptor 7 inhibitor N'-(2-methylphenyl)adamantane-1-c... 3 0
Acyl-CoA:cholesterol acyltransferase inhibitor N-[2,6-di(propa... 1 2
Voltage-dependent L-type calcium channel subunit alpha-1S liga... 1 0
Metabotropic glutamate receptor 2 ligand 4-[4-(methylamino)phe... 1 4
G protein-activated inward rectifier potassium channel 4 and G... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-073NSD f... 1 0
Substance-P receptor ligand AGN-PC-01XQZB family 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 2 0
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3
7-(4-methylpent-3-enylidene)-3-phenyl-2,4a,5,6,8,8a-hexahydrop... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00100115 DAP001082 Approved Drug Vorinostat
CFAMM00100067 DNC008315 Investigative Drug (Z)-2,6-diisopropyl-N-phenyloctadec-9-enamide
CFAMM00100181 DNC008050 Investigative Drug N8-hydroxy-2-methoxy-N1-phenyloctanediamide
CFAMM00100221 DNC010703 Investigative Drug N-(3,5-Dimethylphenyl)-N'-hydroxyoctanediamide
CFAMM00100235 DNC004808 Investigative Drug Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester
CFAMM00100171 DNC004804 Investigative Drug 6-Mercapto-hexanoic acid phenylamide
CFAMM00100227 DNC010705 Investigative Drug N-(3,4-Dimethylphenyl)-N'-hydroxyoctanediamide
CFAMM00100180 DNC008051 Investigative Drug N8,2-dihydroxy-N1-phenyloctanediamide
CFAMM00100232 DNC004802 Investigative Drug 7-Mercapto-heptanoic acid phenylamide
CFAMM00100226 DNC010704 Investigative Drug N-(3-Ethylphenyl)-N'-hydroxyoctanediamide
CFAMM00100168 DNC004803 Investigative Drug 8-Mercapto-octanoic acid phenylamide
CFAMM00100231 DNC014757 Investigative Drug (E)-Octadec-9-enoic acid phenylamide
CFAMM00100195 DNC010712 Investigative Drug N-(2-Ethylphenyl)-N'-hydroxyoctanediamide
CFAMM00100188 DNC010709 Investigative Drug N-(4-Ethylphenyl)-N'-hydroxyoctanediamide
CFAMM00100224 DNC010706 Investigative Drug N-Hydroxy-N'-(3-methylphenyl)octanediamide
CFAMM00100197 DNC010714 Investigative Drug N-(2,5-Dimethylphenyl)-N'-hydroxyoctanediamide
CFAMM00100194 DNC010713 Investigative Drug N-(2,3-Dimethylphenyl)-N'-hydroxyoctanediamide
CFAMM00100069 DNC013519 Investigative Drug 9-mercapto-8-oxo-N-phenylnonanamide
CFAMM00100037 DNC005568 Investigative Drug 2-Cyclohexyl-N-phenyl-acetamide
CFAMM00100218 DNC010708 Investigative Drug N-Hydroxy-N'-(4-methylphenyl)octanediamide
CFAMM00100061 DNC003647 Investigative Drug 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide
CFAMM00100196 DNC010715 Investigative Drug N-(2,6-Dimethylphenyl)-N'-hydroxyoctanediamide
CFAMM00100193 DNC010710 Investigative Drug N-Hydroxy-N'-(2-methylphenyl)octanediamide
CFAMM00100079 DNC009660 Investigative Drug N-phenyl-6-(sulfamoylamino)hexanamide
CFAMM00100192 DNC010711 Investigative Drug N-(2,4-Dimethylphenyl)-N'-hydroxyoctanediamide
CFAMM00100172 DNC007076 Investigative Drug Oleic Acid Anilide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22645 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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