CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD744
Family Name Kappa-type opioid receptor Ligand Dezocine Family
No. of Seeds 36 No. of Other Members 46
Family Centroid CFAMM00100318 Functional Category Approved Drug
Superfamily Kappa-type opioid receptor Ligand Dezocine Superfamily
Class Class 62

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Opioid receptor ligand opiate Levorphanol Family 18 537
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Alpha-2 adrenergic receptor Ligand Oxymetazoline Family 5 4
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Mu-type opioid receptor Ligand Alvimopan Family 32 325
D(2) dopamine receptor Ligand Quinagolide Family 2 0
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Zucapsacin family 7 177
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
D(2) dopamine receptor Ligand N-0923 Family 6 41
D(3) dopamine receptor Ligand U-99194A Family 7 33
CORT-108297 family 46 44
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
D(2) dopamine receptor and D(1A) dopamine receptor Ligand A-70... 16 27
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Histamine H3 receptor Ligand A-331440 Family 6 7
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Amine oxidase [flavin-containing] B Inhibitor 5-hydroxy-n-prop... 3 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 0
Acetylcholinesterase and Cholinesterase Inhibitor N,n'-(1',10'... 12 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
4-aminobutyrate aminotransferase, mitochondrial Inhibitor 4-hy... 2 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Mu-type opioid receptor Ligand Cyprodime Family 12 8
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
D(1A) dopamine receptor Ligand 5-(2-amino-ethyl)-2-chloro-phen... 1 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 3 1
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 20 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TF5... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TFC... 2 7
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 1
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 7 5
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-01Z... 2 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
D(2) dopamine receptor and D(1A) dopamine receptor ligand (2R,... 3 2
D(3) dopamine receptor ligand S 14297 family 1 2
Sigma non-opioid intracellular receptor 1 ligand CHEMBL154452 ... 2 1
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
D(1A) dopamine receptor ligand (5R)-8-bromo-3-methyl-5-phenyl-... 6 15
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 2
D(2) dopamine receptor and D(1A) dopamine receptor ligand (6aR... 2 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
Transporter and Sodium-dependent serotonin transporter inhibit... 1 5
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Kinesin-like protein KIF11 inhibitor 3-[2-aminoethylsulfanyl-(... 2 5
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Kappa-type opioid receptor ligand CHEMBL2367762 family 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 4
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 3
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-006SR... 1 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 5
Phenethylamines Metabolite Tyramine-O-sulfate Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00100318 DAP001100 Approved Drug Dezocine
CFAMM00100372 CHEMBL2367796 Bioactive CHEMBL2367796
CFAMM00100333 CHEMBL133830 Bioactive 41363-00-2
CFAMM00100340 CHEMBL98883 Bioactive CHEMBL98883
CFAMM00100371 CHEMBL2367798 Bioactive CHEMBL2367798
CFAMM00100377 CHEMBL351782 Bioactive SureCN8673895
CFAMM00100370 CHEMBL1256959 Bioactive (+/-)-N-Allylnormetazocine hydrochloride
CFAMM00100353 CHEMBL104169 Bioactive (6R,7S)-7-amino-8,8-dimethyl-6-methylsulfanyl-6,7-dihydro-5H-naphthalen-2-ol
CFAMM00100382 CHEMBL2311194 Bioactive CHEMBL2311194
CFAMM00100322 CHEMBL108068 Bioactive CHEMBL108068
CFAMM00100336 CHEMBL420995 Bioactive CHEMBL420995
CFAMM00100374 CHEMBL2367790 Bioactive CHEMBL2367790
CFAMM00100344 CHEMBL294226 Bioactive AGN-PC-074B6Z
CFAMM00100351 CHEMBL347700 Bioactive (7R,8S)-8-prop-2-enyl-7-(propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
CFAMM00100357 CHEMBL106432 Bioactive (6R,7S)-7-amino-6-methoxy-8,8-dimethyl-6,7-dihydro-5H-naphthalen-2-ol
CFAMM00100373 CHEMBL2367797 Bioactive CHEMBL2367797

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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