CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD749
Family Name Muscarinic acetylcholine receptor Ligand Methantheline Family
No. of Seeds 6 No. of Other Members 8
Family Centroid CFAMM00100780 Functional Category Approved Drug with Natural Product
Superfamily Muscarinic acetylcholine receptor Ligand Methantheline Superfamily
Class Class 572

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Sodium- and chloride-dependent GABA transporter 3 Inhibitor SN... 1 4
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Sodium-dependent dopamine transporter and Sodium-dependent ser... 4 1
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL1... 5 5
C-C chemokine receptor type 3 and Histamine H1 receptor ligand... 2 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-074R8E family 2 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Putative NP ZINC04043753 Family 8 6
Putative NP ZINC04029215 Family 6 0
3-pentyl-5-(phenoxymethyl)oxolan-2-one NP ZINC02116245 Family 4 0
4-carboxylate NP ZINC04340771 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00100775 DAP001123 Approved Drug Propantheline
CFAMM00100780 DAP001109 Approved Drug Methantheline
CFAMM00100788 CHEMBL1788286 Bioactive [(3S)-1-azabicyclo[2.2.2]octan-3-yl] 9H-xanthene-9-carboxylate
CFAMM00100787 CHEMBL559106 Bioactive SureCN157068
CFAMM00100778 CHEMBL1180725 Bioactive propantheline
CFAMM00100776 CHEMBL549577 Bioactive AC1LIVNS

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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