CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD75
Family Name Alpha-1B adrenergic receptor ligand phenethylamine derivative Dextroamphetamine family
No. of Seeds 12 No. of Other Members 283
Family Centroid CFAMM00016340 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Biogenic amine receptor, re-uptake and enxyme binding amphetamine phenethylamine Superfamily
Class Class 73

Cousin Family NamesSeedsMembers
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
AMP-activated protein kinase Inhibitor Phenformin Family 5 14
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Alpha adrenergic receptor Ligand Tolazoline Family 7 51
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] B Inhibitor Phenelzine Family 7 15
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41
Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
C-X-C chemokine receptor type 4 Ligand AMD-3100 Family 3 6
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 3 12
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
Sphingosine 1-phosphate receptor 1 Ligand [3-(4-nonyl-benzylam... 9 22
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
5-hydroxytryptamine receptor 6 Ligand 2-(3-benzenesulfonyl)phe... 3 4
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 6 24
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 15 11
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Amine oxidase [flavin-containing] A Inhibitor Trans-(+/-)-2-fl... 2 0
Aminopeptidase N Inhibitor (1-amino-2-phenyl-ethyl)-phosphinic... 3 11
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
5-hydroxytryptamine receptor 2A Ligand 1-(4-bromo-2,5-difluoro... 1 5
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 4
Sodium-dependent serotonin transporter Inhibitor 2-n-ethylamin... 14 5
Sigma non-opioid intracellular receptor 1 ligand 2-(3-iodophen... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-003L8Y... 2 4
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor Sodium... 1 10
Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 5
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Prelamin-A/C inhibitor CHEMBL1353052 family 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor (1... 3 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor 1-(sul... 1 0
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 3 1
NP (1-isothiocyanatoethyl)benzene Family 2 6
1-[(E)-3-phenylprop-2-enyl]-4-[[(4S)-4-prop-1-en-2-ylcyclohexe... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00016340 DAP000572 Approved Drug Dextroamphetamine
CFAMM00016156 DAP000573 Approved Drug Methamphetamine
CFAMM00016470 DAP001146 Approved Drug Amphetamine
CFAMM00016198 DAP000081 Approved Drug Tranylcypromine
CFAMM00016284 CHEMBL2092973 Bioactive SureCN1006211
CFAMM00016409 DNC011448 Investigative Drug p-IODOAMPHETAMINE
CFAMM00016223 DNC009552 Investigative Drug cis-2-fluoro-2-phenylcyclopropanamine
CFAMM00016222 DNC009553 Investigative Drug cis-2-phenylcyclopropylamine
CFAMM00016329 DNC009548 Investigative Drug trans-2-fluoro-2-phenylcyclopropylamin
CFAMM00016177 DNC012126 Investigative Drug (S)-2-Amino-3-phenyl-propane-1-thiol
CFAMM00016327 DNC009545 Investigative Drug trans-2-fluoro-2-p-tolylcyclopropanamine
CFAMM00016326 DNC009544 Investigative Drug cis-(+/-)-2-Fluoro-1,2-diphenylcyclopropylamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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