CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD752
Family Name Muscarinic acetylcholine receptor Ligand Flavoxate Family
No. of Seeds 9 No. of Other Members 350
Family Centroid CFAMM00101170 Functional Category Approved Drug with Natural Product
Superfamily Muscarinic acetylcholine receptor Ligand Flavoxate Superfamily
Class Class 288

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Potassium voltage-gated channel subfamily H member 2 Ligand Am... 2 16
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
Ipriflavone family 62 2480
Rotenone family 16 107
Agrimophol family 10 22
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Acolbifene family 10 115
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Interleukin-1 beta Inhibitor Diacerein Family 3 77
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
DNA-dependent protein kinase catalytic subunit Inhibitor 2-pyr... 2 2
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 46
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Androgen receptor Ligand Palodesangren E Family 12 43
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor 2-[3-[(1R... 9 46
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 8
Sodium-dependent dopamine transporter and Sigma non-opioid int... 7 5
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 3 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Histamine H1 receptor and Cysteinyl leukotriene receptor 1 lig... 1 15
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Prelamin... 1 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 1
Lanosterol synthase inhibitor AC1L9UWE family 1 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 3
Squalene--hopene cyclase and Lanosterol synthase inhibitor R17... 1 22
Multidrug resistance protein 1 inhibitor CHEMBL1 family 2 0
Breast cancer type 1 susceptibility protein and Huntingtin inh... 1 7
Cholesteryl ester transfer protein inhibitor [8-[(1S)-1-hydrox... 4 10
Reverse transcriptase/RNaseH inhibitor AC1O5COS family 1 0
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 2 110
Cathepsin D inhibitor (E)-N-butyl-4-[1-(3,4,5-trimethoxybenzoy... 1 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
Multidrug resistance protein 1 inhibitor 1-[4-[(2R)-2-hydroxy-... 1 0
Estrogen receptor ligand AGN-PC-073KIM family 1 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor (2Z)-... 2 10
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 11
NP (z)-2-(4-isopropylbenzylidene)-3-oxo-2,3-dihydrobenzofuran-... 16 0
2-amino-3-methylpentanoate NP 2-((3-(4-fluorophenoxy)-4-oxo-4h... 13 2
Putative NP ZINC08878071 Family 9 2
Putative NP ZINC00174842 Family 4 0
NP Ethyl 4-(2-((5-hydroxy-2,2-dimethyl-4-oxochroman-7-yl)oxy)a... 4 0
methoxybenzoate NP ZINC04028167 Family 2 0
NP 7-(2-((4as,8as)-4a-hydroxyoctahydroisoquinolin-2(1h)-yl)-2-... 3 0
hydroxyspiro[3H-chromene-2,4'-piperidine]-4-one NP 1'-acetyl-7... 2 1
ethylcarbamate NP ZINC09486061 Family 3 0
NP Agn-pc-05g5on Family 11 0
NP 3-(4-chlorophenyl)-4-oxo-4h-chromen-7-yl Diethylcarbamate F... 6 0
Putative NP ZINC02424496 Family 5 0
9,10-dihydro-8H-pyrano[2,3-f][1,3]benzoxazin-9-ium-2-one NP Ag... 6 0
NP 2-amino-7-[(2,6-dichlorophenyl)methoxy]-3-(4-methoxyphenyl)... 4 0
Putative NP ZINC09192007 Family 4 0
4-carboxylate NP ZINC04340771 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00101170 DAP001114 Approved Drug Flavoxate
CFAMM00101079 DCL000600 Clinical Trial Drug LY294002
CFAMM00100962 DNC005965 Investigative Drug 8-(2-acetylphenyl)-2-morpholin-4-ylchromen-4-one
CFAMM00100928 DNC004365 Investigative Drug 2-Morpholin-4-yl-8-phenylethynyl-chromen-4-one
CFAMM00101031 DNC005955 Investigative Drug 8-(4-acetylphenyl)-2-morpholin-4-ylchromen-4-one
CFAMM00101167 DNC006240 Investigative Drug 8-methyl-2-morpholino-7-phenoxy-4H-chromen-4-one
CFAMM00100959 DNC005962 Investigative Drug 8-furan-2-yl-2-morpholin-4-ylchromen-4-one
CFAMM00100864 DNC004822 Investigative Drug 2-(4-Benzyl-piperidin-1-ylmethyl)-chroman-4-one
CFAMM00100963 DNC005966 Investigative Drug 2-morpholin-4-yl-8-styrylchromen-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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