CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Muscarinic acetylcholine receptor Ligand Mepenzolate Family
No. of Seeds 35 No. of Other Members 11
Family Centroid CFAMM00101252 Functional Category Approved Drug
Superfamily Muscarinic acetylcholine receptor ligand Oxyphencyclimine Mepenzolate Oxyphenonium Superfamily
Class Class 474

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Histamine H1 receptor Ligand Terfenadine Family 3 50
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
Muscarinic acetylcholine receptor Ligand Flutropium Bromide Fa... 6 45
Muscarinic acetylcholine receptor M2 ligand Tropane alkaloid S... 7 16
Muscarinic acetylcholine receptor M5 ligand Tropane alkaloid A... 18 12
Sodium channel protein type 5 subunit alpha Ligand Hexylcaine ... 4 94
Muscarinic acetylcholine receptor Ligand Oxyphencyclimine Family 1 2
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Muscarinic acetylcholine receptor Ligand Cyclopentolate Family 10 11
Muscarinic acetylcholine receptor M1 Ligand Oxyphenonium Family 12 5
Sodium-dependent dopamine transporter Inhibitor Ioflupane I-12... 130 181
Sodium-dependent noradrenaline transporter Inhibitor (r)-1-((s... 3 8
Cholinesterase Inhibitor 4-[4-(benzyloxy)piperidino]butyl-3-fl... 5 18
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 11 20
Sigma non-opioid intracellular receptor 1 ligand SureCN5315520... 3 11
Sigma non-opioid intracellular receptor 1 ligand methyl (1R,2S... 4 0
Muscarinic acetylcholine receptor M3 ligand SureCN13330671 family 17 1
Muscarinic acetylcholine receptor M3 ligand (1,1-dimethylpiper... 7 1
Squalene synthase inhibitor AGN-PC-075U4N family 3 3
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 6 0
Benzyl Alcohols and Derivatives Metabolite Secodemethylclausen... 1 1


External ID

Functional Category

Molecule Name

CFAMM00101252 DAP001115 Approved Drug Mepenzolate
CFAMM00101251 DAP001117 Approved Drug Clidinium
CFAMM00101263 CHEMBL342669 Bioactive Ditran JB 318
CFAMM00101254 CHEMBL558910 Bioactive AC1LEMBN
CFAMM00101282 CHEMBL343290 Bioactive AGN-PC-01MHOL
CFAMM00101253 CHEMBL2112942 Bioactive AGN-PC-07576N
CFAMM00101268 CHEMBL2115342 Bioactive [(3R)-1-azabicyclo[2.2.2]octan-3-yl] (2R)-2-hydroxy-2-phenylpropanoate
CFAMM00101281 CHEMBL142136 Bioactive NSC170439
CFAMM00101245 CHEMBL143228 Bioactive Enpiperate
CFAMM00101261 CHEMBL21812 Bioactive [(3R)-1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl] (2R)-2-cyclohexyl-2-hydroxy-2-phenylacetate;iodide
CFAMM00101274 CHEMBL298085 Bioactive 1-azabicyclo[2.2.2]octan-3-yl (2R)-2-hydroxy-2-(4-iodophenyl)-2-phenylacetate
CFAMM00101267 CHEMBL1628654 Bioactive [3H]QNB
CFAMM00101244 CHEMBL49576 Bioactive 1-azabicyclo[2.2.2]octan-3-yl (2R)-2-[4-(2-fluoroethyl)phenyl]-2-hydroxy-2-phenylacetate
CFAMM00101260 CHEMBL423551 Bioactive 3-Piperidyl benzilate
CFAMM00101273 CHEMBL343764 Bioactive (1-ethylpiperidin-4-yl) 2-hydroxy-2,2-diphenylacetate
CFAMM00101279 CHEMBL2111842 Bioactive [(3R)-1-azabicyclo[2.2.2]octan-3-yl] (Z,2R)-2-hydroxy-5-iodo-2-phenylpent-4-enoate
CFAMM00101266 CHEMBL1788199 Bioactive [(3S)-1-azabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2,2-diphenylacetate
CFAMM00101243 CHEMBL21905 Bioactive (1,1-dimethylpiperidin-1-ium-4-yl) (2R)-2-cyclohexyl-2-hydroxy-2-phenylacetate;iodide
CFAMM00101259 CHEMBL141397 Bioactive AGN-PC-075OIX
CFAMM00101272 CHEMBL336052 Bioactive AGN-PC-00GA78
CFAMM00101250 CHEMBL1398637 Bioactive [(3R)-1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2,2-diphenylacetate
CFAMM00101258 CHEMBL141559 Bioactive [1-(2-fluoroethyl)piperidin-4-yl] 2-hydroxy-2,2-diphenylacetate
CFAMM00101271 CHEMBL141842 Bioactive [1-(2-phenylethyl)piperidin-4-yl] 2-hydroxy-2,2-diphenylacetate
CFAMM00101277 CHEMBL107796 Bioactive [(3R)-1-azabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2-phenylpropanoate
CFAMM00101280 DNCL002662 Clinical Trial Drug CG201

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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