CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD758
Family Name Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methylsulfate Family
No. of Seeds 22 No. of Other Members 45
Family Centroid CFAMM00101376 Functional Category Approved Drug
Superfamily Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methylsulfate Superfamily
Class Class 578

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibu... 7 127
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Muscarinic acetylcholine receptor M5 Ligand Metixene Family 5 24
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Beta adrenergic receptor Ligand Bretylium Family 3 11
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
Dermatan family 1 11
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Substance-P receptor Ligand Vestipitant Family 14 137
Pitolisant family 4 24
Zicronapine family 43 62
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Peptide deformylase, mitochondrial Inhibitor [hydroxy(3-phenyl... 1 0
Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 12 20
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
Potassium voltage-gated channel subfamily H member 2 Ligand 4-... 4 26
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Sodium-dependent serotonin transporter Inhibitor Tefludazine F... 8 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
5-hydroxytryptamine receptor 1A Ligand 2-(biphenyl-3-ylthio)-n... 1 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 4
Squalene synthase Inhibitor Zwitterionic Sulfobetaine Derivati... 2 20
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[2-... 3 3
Sigma non-opioid intracellular receptor 1 ligand 2-(3-iodophen... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
5-hydroxytryptamine receptor 7 ligand 5-methyl-6-(6-methyl-5,6... 2 0
Sigma non-opioid intracellular receptor 1 and 3-beta-hydroxyst... 4 12
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-methoxy-1-[(2S)-... 2 0
Muscarinic acetylcholine receptor M3 ligand 3-[8-(2-methoxyeth... 3 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 10
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Sigma non-opioid intracellular receptor 1 ligand 1-[2-[4-[1-ad... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
Sigma non-opioid intracellular receptor 1 ligand 1-benzyl-4-[(... 3 2
Sigma non-opioid intracellular receptor 1 ligand 4-benzyl-1-[(... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 5
Histamine H3 receptor ligand SureCN1641166 family 3 0
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4
Histamine H3 receptor ligand (3aR,6aR)-2-propan-2-yl-4-[4-(2-p... 6 5
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
D(1A) dopamine receptor and D(2) dopamine receptor ligand A314... 3 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 12
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
D(2) dopamine receptor ligand AGN-PC-041NNJ family 1 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
1-benzyl-3,6-diazatricyclo[4.3.1.1~3,8~]undecan-9-amine NP ZIN... 2 1
1-[(E)-3-phenylprop-2-enyl]-4-[[(4S)-4-prop-1-en-2-ylcyclohexe... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00101376 DAP001130 Approved Drug Diphemanil Methylsulfate
CFAMM00101383 CHEMBL39807 Bioactive 1-(2-cyclohexylethyl)-3-[(Z)-2-phenylethenyl]piperidine
CFAMM00101360 CHEMBL1917705 Bioactive 1-[(E)-3-(4-phenylphenyl)but-2-enyl]piperidine;hydrochloride
CFAMM00101404 CHEMBL178153 Bioactive SureCN7409408
CFAMM00101412 CHEMBL71883 Bioactive AGN-PC-074GM3
CFAMM00101359 CHEMBL20188 Bioactive Piperidine, 1-(5-phenylpentyl)-
CFAMM00101374 CHEMBL287937 Bioactive 3-[(E)-2-phenylethenyl]-1-(2-phenylethyl)piperidine
CFAMM00101403 CHEMBL67808 Bioactive AGN-PC-074GKB
CFAMM00101351 CHEMBL37661 Bioactive 3-[(E)-2-phenylethenyl]-1-(3-phenylpropyl)piperidine
CFAMM00101381 CHEMBL1917719 Bioactive 1-[3-(4-phenylphenyl)butyl]piperidine;hydrochloride
CFAMM00101364 CHEMBL72045 Bioactive AGN-PC-074GQI
CFAMM00101387 CHEMBL302087 Bioactive 1-(5,5-diphenylpentyl)-4-methylpiperidine
CFAMM00101363 CHEMBL39818 Bioactive 1-(4-phenylbutyl)-3-[(Z)-2-phenylethenyl]piperidine
CFAMM00101362 CHEMBL304079 Bioactive 4-methyl-1-(5-phenylpentyl)piperidine
CFAMM00101355 DNC003871 Investigative Drug Prodipine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45558 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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