CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD76
Family Name Thyroid hormone receptor alpha ligand thyroid hormone analog Liothyronine family
No. of Seeds 10 No. of Other Members 61
Family Centroid CFAMM00016553 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Thyroid hormone receptor alpha ligand thyroid hormone analog Liothyronine Superfamily
Class Class 74

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Prostaglandin G/H synthase 1 Inhibitor (3-chloro-4-propoxy-phe... 2 10
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42
Thyroid hormone receptor beta Ligand (3,5-dibromo-4-pentyloxy-... 5 21
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 8 14
Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0
Kinesin-like protein KIF11 inhibitor 2-amino-5-(4-methoxypheny... 1 4
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 3 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
72 kDa type IV collagenase and Collagenase 3 inhibitor 2-[(3Z)... 4 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 2 1
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
Free fatty acid receptor 1 ligand 3-[4-[2-[2-(cyanomethoxy)phe... 1 2
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 2
Thioredoxin glutathione reductase and Beta-lactamase inhibitor... 1 0
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Tyrosine-protein phosphatase non-receptor type 1 ligand FLUORO... 1 1
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Putative NP ZINC04043753 Family 8 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00016554 DAP000083 Approved Drug Levothyroxine
CFAMM00016553 DAP000082 Approved Drug Liothyronine
CFAMM00016491 CHEMBL559 Bioactive D-Thyroxine
CFAMM00016570 CHEMBL41314 Bioactive SureCN9619560
CFAMM00016506 CHEMBL182339 Bioactive SureCN12238389
CFAMM00016559 CHEMBL235173 Bioactive AC1O5D8M
CFAMM00016513 CHEMBL291053 Bioactive THYROPROPIC ACID
CFAMM00016484 CHEMBL105983 Bioactive o-(4-hydroxy-3-isopropylphenyl)-3,5-dimethyl-l-tyrosine
CFAMM00016530 DNC006283 Investigative Drug Detrothyronine
CFAMM00016529 DNC011372 Investigative Drug LIOTHYRONINE SODIUM

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543