CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Mu-type opioid receptor Ligand Diphenoxylate Family
No. of Seeds 5 No. of Other Members 6
Family Centroid CFAMM00101496 Functional Category Approved Drug with Natural Product
Superfamily Histamine H1 receptor and Mu-type opioid receptor Binder Superfamily
Class Class 232

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
Histamine H1 receptor Ligand Levocabastine Family 1 1
Muscarinic acetylcholine receptor M5 ligand Tropane alkaloid A... 18 12
DNA Binder Procarbazine Family 8 358
Muscarinic acetylcholine receptor Ligand Cyclopentolate Family 10 11
Mu-type opioid receptor Ligand Anileridine Family 3 18
Mu-type opioid receptor ligand opiate Methadyl Acetate Family 5 9
Sodium-dependent dopamine transporter Inhibitor Ioflupane I-12... 130 181
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Cholinesterase Inhibitor 4-[4-(benzyloxy)piperidino]butyl-3-fl... 5 18
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 8 30
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 1
Sodium-dependent serotonin transporter and Transporter inhibit... 6 9
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Sodium-dependent dopamine transporter inhibitor methyl (2R)-2-... 1 0
Sigma non-opioid intracellular receptor 1 ligand methyl (1S,2R... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-07BZ08... 1 0
Sodium-dependent dopamine transporter and Transporter inhibito... 1 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor me... 2 0
DNA polymerase beta and Muscleblind-like protein 1 inhibitor C... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 4
Putative NP ZINC04084382 Family 8 0
3-[(4-benzoylpiperidin-1-ium-1-yl)methyl]-8a-methyl-5-methylid... 8 0
Putative NP ZINC04073334 Family 30 0
[(1R,9aR)-1,2,3,4,5,6,7,8,9,9a-decahydroquinolizin-5-ium-1-yl]... 1 0


External ID

Functional Category

Molecule Name

CFAMM00101496 DAP001136 Approved Drug Diphenoxylate
CFAMM00101493 CHEMBL41677 Bioactive AGN-PC-073NI9
CFAMM00101497 CHEMBL1289748 Bioactive AGN-PC-09M9O0
CFAMM00101490 CHEMBL1290741 Bioactive AGN-PC-09M8CK
CFAMM00101488 CHEMBL1288490 Bioactive AGN-PC-09M8BG

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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