CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Mu-type opioid receptor ligand opiate Methadyl Acetate Family
No. of Seeds 5 No. of Other Members 9
Family Centroid CFAMM00101513 Functional Category Approved Drug
Superfamily opioid receptor, adrenergic receptor ligand opiate Acetylmethadol Meperidine Superfamily
Class Class 174

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Histamine H1 receptor Ligand Terfenadine Family 3 50
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Muscarinic acetylcholine receptor Ligand Cyclopentolate Family 10 11
Mu-type opioid receptor Ligand Diphenoxylate Family 5 6
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Potassium voltage-gated channel subfamily H member 2 Ligand [1... 2 23
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-ri... 5 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 19
Vesicular acetylcholine transporter inhibitor BENZOVESAMICOL f... 7 4
Vesicular acetylcholine transporter inhibitor 2-Naphthalenol, ... 3 2
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 1 2
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 12
Vesicular acetylcholine transporter inhibitor (1R,2R)-2-spiro[... 3 2
Vesicular acetylcholine transporter inhibitor (4aR,6R,7R,8aR)-... 4 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 4
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-07BZ08... 1 0
Alpha-1A adrenergic receptor and Transporter ligand AGN-PC-00M... 2 2
Membrane primary amine oxidase and Amine oxidase [flavin-conta... 2 0
Voltage-dependent N-type calcium channel subunit alpha-1B and ... 1 3
Dibenzocycloheptenes Metabolite E-10-Hydroxynortriptyline Family 1 0
7-phenyl-1,3-diazaadamantan-6-ol NP ZINC32124180 Family 5 0
Putative NP ZINC55525127 Family 1 2


External ID

Functional Category

Molecule Name

CFAMM00101513 DAP001137 Approved Drug Methadyl Acetate
CFAMM00101511 DAP001139 Approved Drug Levomethadyl Acetate
CFAMM00101498 DNC012118 Investigative Drug 6-(Allyl-methyl-amino)-4,4-diphenyl-heptan-3-ol
CFAMM00101505 DNC012107 Investigative Drug Dimepheptanol

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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