CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD765
Family Name Mu-type opioid receptor Ligand Alvimopan Family
No. of Seeds 32 No. of Other Members 325
Family Centroid CFAMM00101882 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Mu-type opioid receptor Ligand Alvimopan Superfamily
Class Class 323

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Alpha-1 adrenergic receptor ligand arylethanolamine derivative... 4 37
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Opioid receptor ligand opiate Levorphanol Family 18 537
Oxytocin receptor Ligand Oxytocin Family 30 182
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Penicillin binding protein Inhibitor Cefadroxil Family 5 17
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Zucapsacin family 7 177
Eptazocine Hbr family 6 8
Thymopentin family 20 133
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Plitidepsin family 15 5
Flovagatran family 12 546
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Tryptase Inhibitor APC-366 Family 2 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Caspase-1 Inhibitor Yvad Family 1 0
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU84687 F... 2 14
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Acetylcholinesterase and Cholinesterase Inhibitor N,n'-(1',10'... 12 8
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-n-diethyl Estrad... 6 16
Histamine H3 receptor Ligand A-349821 Family 49 228
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-ethyl Estrone-16... 3 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-isopropyl Estrad... 3 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 8
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 3 0
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 7 5
Interstitial collagenase and Low affinity immunoglobulin epsil... 1 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Sodium-dependent dopamine transporter and Sodium-dependent ser... 4 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Tyrosine--tRNA ligase, cytoplasmic inhibitor (2S)-2-[[(2S)-2-a... 5 2
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 5 0
Pol polyprotein inhibitor AC1LADQG family 7 1
Pol polyprotein inhibitor MDL 74538 family 11 1
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 1 0
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 2 1
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Delta-type opioid receptor ligand N-[(1S,4R,5R,7S)-5-(3-hydrox... 2 0
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyp... 4 1
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 5
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 2 1
Prothrombin inhibitor (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]... 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 1 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Gonadotropin-releasing hormone receptor ligand (3R,6S,12S,15S,... 1 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 4
N-acetylated-alpha-linked acidic dipeptidase 2 inhibitor (2S)-... 1 5
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
5-hydroxytryptamine receptor 1A ligand 8-[4-[[(2S)-5-fluoro-8-... 4 3
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
Sodium-dependent dopamine transporter inhibitor AC1MIIGH family 2 0
Kappa-type opioid receptor ligand dimethyl 2,4-bis(4-methoxyph... 2 1
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-076B5T fa... 1 0
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 5
Sigma non-opioid intracellular receptor 1 ligand N-(1-benzylpi... 1 0
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
N-formyl-2-(4-hydroxyphenyl)acetamide NP Agn-pc-04a0ox Family 1 1
7-[(1R,2R)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]-N-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00101882 DAP001140 Approved Drug Alvimopan
CFAMM00101724 CHEMBL212752 Bioactive (2R)-N-[(1S,4R,5R,7S)-5-(3-hydroxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-yl]-2-phenylpropanamide
CFAMM00101843 CHEMBL10986 Bioactive 3-(4-hydroxyphenyl)-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]propanamide
CFAMM00101612 CHEMBL109327 Bioactive (2S)-2-[[(2R)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-(2,6-dimethylphenyl)propanoyl]amino]-4-methylpentanoic acid
CFAMM00101554 CHEMBL256010 Bioactive SureCN9988464
CFAMM00101842 CHEMBL404303 Bioactive SureCN9989634
CFAMM00101835 CHEMBL401716 Bioactive SureCN3452528
CFAMM00101890 CHEMBL100480 Bioactive (2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
CFAMM00101595 CHEMBL255354 Bioactive SureCN9988510
CFAMM00101657 CHEMBL401789 Bioactive SureCN9988501
CFAMM00101827 CHEMBL111028 Bioactive (2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-(2,6-dimethylphenyl)propanoyl]amino]-4-methylpentanoic acid
CFAMM00101715 CHEMBL117457 Bioactive N-[(7R)-5-(3-hydroxyphenyl)-4-methyl-2-(2-phenylethyl)-2-azabicyclo[3.3.1]nonan-7-yl]-3-piperidin-1-ylpropanamide
CFAMM00101741 CHEMBL437983 Bioactive SureCN9988525
CFAMM00101798 CHEMBL401615 Bioactive SureCN9990176
CFAMM00101528 CHEMBL403633 Bioactive SureCN9988916
CFAMM00101833 CHEMBL401508 Bioactive SureCN9989560
CFAMM00101601 CHEMBL387245 Bioactive delmorphan-A
CFAMM00101754 CHEMBL384406 Bioactive N-[(1S,4R,5R,7S)-5-(3-hydroxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-yl]-1-phenylcyclohexane-1-carboxamide
CFAMM00101557 CHEMBL270187 Bioactive SureCN9989589
CFAMM00101648 CHEMBL403325 Bioactive SureCN9988902
CFAMM00101726 CHEMBL73233 Bioactive SureCN3770468
CFAMM00101753 CHEMBL2114114 Bioactive 2-methylpropyl 2-[[2-benzyl-3-[4-(3-hydroxyphenyl)piperidin-1-yl]propanoyl]amino]acetate
CFAMM00101831 CHEMBL402964 Bioactive SureCN9989601
CFAMM00101859 CHEMBL403190 Bioactive SureCN1212555
CFAMM00101564 CHEMBL308501 Bioactive AC1O716O
CFAMM00101701 CHEMBL2115154 Bioactive SureCN6274264
CFAMM00101719 CHEMBL212884 Bioactive N-[(1S,4R,5R,7S)-5-(3-hydroxyphenyl)-4-methyl-2-[(E)-3-phenylprop-2-enyl]-2-azabicyclo[3.3.1]nonan-7-yl]-2-methyl-2-phenylpropanamide
CFAMM00101607 CHEMBL151243 Bioactive 3-(4-hydroxyphenyl)-N-[(2S)-1-[4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylpentan-2-yl]propanamide
CFAMM00101851 CHEMBL437140 Bioactive 2-ethyl-N-[(1S,4R,5R,7S)-5-(3-hydroxyphenyl)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-7-yl]-2-phenylbutanamide
CFAMM00101866 CHEMBL270401 Bioactive SureCN9989539
CFAMM00101880 CHEMBL72850 Bioactive 2-[[(2S)-2-benzyl-3-[4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid
CFAMM00101525 CHEMBL421789 Bioactive AGN-PC-01MCYA

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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