CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD771
Family Name Noradrenergic re-uptake Inhibitor Maprotiline Family
No. of Seeds 6 No. of Other Members 33
Family Centroid CFAMM00102036 Functional Category Approved Drug with Human Metabolite
Superfamily Noradrenergic re-uptake Inhibitor Maprotiline Superfamily
Class Class 585

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
Substance-P receptor Ligand Vestipitant Family 14 137
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Amine oxidase [flavin-containing] A Inhibitor Trans-(+/-)-2-fl... 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 2
D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-003L8Y... 2 4
Substance-P receptor ligand AGN-PC-03NGZZ family 1 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
Sigma non-opioid intracellular receptor 1 ligand 1-[2-[4-[1-ad... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 5
Histamine H3 receptor ligand SureCN1641166 family 3 0
Histamine H3 receptor ligand 4-[6-(2-pyrrolidin-3-ylethyl)naph... 1 1
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Prostatic acid phosphatase inhibitor Phosphonic acid, [1-napht... 1 0
Kinesin-like protein KIF11 inhibitor 4-(4-chlorophenyl)-4,4-di... 1 2
Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Tetralins Metabolite 1,2,3,4,Tetrahydro-1,5,7-trimethylnapthal... 1 19
1-[(E)-3-phenylprop-2-enyl]-4-[[(4S)-4-prop-1-en-2-ylcyclohexe... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00102036 DAP001150 Approved Drug Maprotiline
CFAMM00102034 DNC010211 Investigative Drug 9-(2-aminopropyl)-9,10-dihydroanthracene
CFAMM00102011 DNC010209 Investigative Drug 9-(2-aminoethyl)-9,10-dihydroanthracene
CFAMM00102025 DNC010210 Investigative Drug 2-(9,10-dihydroanthracen-9-yl)-N-methylethanamine
CFAMM00102009 DNC010283 Investigative Drug 9-(N-benzylaminomethyl)-9,10-dihydroanthracene

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27432 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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