CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD772
Family Name Noradrenergic re-uptake Inhibitor Milnacipran Family
No. of Seeds 7 No. of Other Members 51
Family Centroid CFAMM00102088 Functional Category Approved Drug with Human Metabolite
Superfamily Noradrenergic re-uptake Inhibitor Milnacipran Superfamily
Class Class 586

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Methyl... 9 7
Opioid receptor Ligand Methadone Family 3 39
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
DNA Binder Procarbazine Family 8 358
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 2 9
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Cytochrome P450 2D6 Inhibitor Glutethimide Family 1 1
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Scytalone dehydratase Inhibitor Carpropamid Family 5 2
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 1-(2-... 1 1
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 18
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 6
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 2
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 7 2
Cannabinoid receptor 2 ligand 1-adamantyl(1,3-dihydroisoindol-... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 6
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 3 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Glucose-dependent insulinotropic receptor ligand (1-methylcycl... 4 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00102097 DAP001547 Approved Drug Milnacipran HCl
CFAMM00102088 DAP001155 Approved Drug Milnacipran
CFAMM00102055 CHEMBL99946 Bioactive Levomilnacipran
CFAMM00102083 CHEMBL388657 Bioactive (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-naphthalen-2-ylcyclopropane-1-carboxamide;hydrochloride
CFAMM00102051 CHEMBL259209 Bioactive 2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide
CFAMM00102102 DNC009050 Investigative Drug 1S,2R-milnacipran
CFAMM00102077 DNC008269 Investigative Drug N,Ndimethyl milnacipran

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543