CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD793
Family Name Dihydropterin pyrophosphokinase-dihydropteroate synthase inhibitor benzenesulfonamide derivative Sulfadiazine Family
No. of Seeds 5 No. of Other Members 60
Family Centroid CFAMM00102602 Functional Category Approved Drug with Human Metabolite
Superfamily Dihydropterin pyrophosphokinase-dihydropteroate synthase inhibitor benzenesulfonamide derivative Sulfadiazine Sulfamethazine Superfamily
Class Class 600

Cousin Family NamesSeedsMembers
Dihydropterin pyrophosphokinase-dihydropteroate synthase Inhib... 2 3
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
ATP-sensitive inward rectifier potassium channel 10 Ligand Gly... 1 0
Dihydropterin pyrophosphokinase-dihydropteroate synthase Inhib... 1 1
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 4 14
SUR2-type K(ATP) channel Ligand Pinacidil Family 1 8
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
Transient receptor potential cation channel subfamily V member... 15 457
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Reverse transcriptase Inhibitor Benzothiadiazines Family 4 21
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio... 4 17
Plasminogen and Urokinase-type plasminogen activator Inhibitor... 3 26
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 22
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(met... 4 15
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BIUF2 family 25 11
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 1
Nicotinamide phosphoribosyltransferase and Prelamin-A/C inhibi... 1 0
5-hydroxytryptamine receptor 6 ligand 3-(benzenesulfonyl)-N,5-... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 2 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 1
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Carbonic anhydrase 2 and Carbonic anhydrase 7 inhibitor 4-[(4,... 5 4
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 1 4
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
G1/S-specific cyclin-E1 and G1/S-specific cyclin-E2 inhibitor ... 5 1
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Nicotinamide phosphoribosyltransferase and Cytochrome P450 2C9... 4 5
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... 2 1
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-[3-(2-hydroxyeth... 2 1
Tyrosine-protein kinase ZAP-70 inhibitor AGN-PC-07CO7Z family 1 0
Muscarinic acetylcholine receptor M1 and Cytochrome P450 2C9 l... 2 5
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 1 0
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 1 2
Transient receptor potential cation channel subfamily V member... 2 0
Nonstructural protein 1 and Cruzipain inhibitor CHEMBL1331578 ... 1 2
Metabotropic glutamate receptor 5 ligand AGN-PC-075XWO family 2 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[4-(... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00102602 DAP001238 Approved Drug Sulfadiazine
CFAMM00102615 DAP001200 Approved Drug Sulfapyridine
CFAMM00102614 DAP001321 Approved Drug Silver sulfadiazine
CFAMM00102562 DAP001240 Approved Drug Sulfamerazine
CFAMM00102538 DNC005902 Investigative Drug 4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26816 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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