CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Alpha-2 adrenergic receptor Ligand Yohimbine Family
No. of Seeds 7 No. of Other Members 52
Family Centroid CFAMM00016613 Functional Category Approved Drug with Natural Product
Superfamily Alpha-2 adrenergic receptor Ligand Yohimbine Superfamily
Class Class 78

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Melanin-concentrating hormone receptor 1 Ligand Amg 076 Family 2 8
Toll-like receptor 9 Ligand TLR9 Agonist Family 8 8
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Neuronal acetylcholine receptor subunit beta-4 Ligand 18-metho... 3 0
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 9 3
A disintegrin and metalloproteinase with thrombospondin motifs... 2 12
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 48
Putative NP ZINC00186639 Family 12 0
NP 1-(3-nitrophenyl)-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole... 20 1
1-thiophen-2-yl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-ca... 2 1


External ID

Functional Category

Molecule Name

CFAMM00016635 DNAP001616 Approved Drug Ajmalicine
CFAMM00016613 DAP000087 Approved Drug Yohimbine
CFAMM00016645 DNC012006 Investigative Drug AKUAMMIGINE
CFAMM00016602 DNC009968 Investigative Drug Yohimbine Hydrochloride
CFAMM00016612 DNC003964 Investigative Drug CORYNANTHEINE
CFAMM00016658 DNC000938 Investigative Drug Methylglyoxal (bis) guanylhydrazone
CFAMM00016649 DNC011967 Investigative Drug RAUWOLFIA SERPENTINA ROOT

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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