CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD805
Family Name Renin Inhibitor Aliskiren Family
No. of Seeds 28 No. of Other Members 107
Family Centroid CFAMM00102916 Functional Category Approved Drug with Natural Product
Superfamily Renin Inhibitor Aliskiren Superfamily
Class Class 609

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Zucapsacin family 7 177
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Substance-P receptor Ligand DA-5018 Family 14 73
Ceramide glucosyltransferase Inhibitor Eliglustat Tartrate Family 3 2
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Tubulin beta chain Inhibitor 6-ile-ustiloxin Family 4 3
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
Serine palmitoyltransferase 1 and Serine palmitoyltransferase ... 2 1
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Transient receptor potential cation channel subfamily V member... 3 18
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Renin inhibitor [(1S,3R,4S)-3-amino-4-hydroxycyclopentyl]-[(3R... 2 3
Pol polyprotein inhibitor MDL 74538 family 11 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
Pol polyprotein inhibitor AC1LA3AI family 5 9
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
Renin inhibitor methyl N-[[5-[[(2S,3S,5R)-2-amino-6-(butylamin... 1 0
Stromelysin-1 inhibitor (2R)-2-[[(2S)-1-[(6S)-6-(methylcarbamo... 1 1
Renin inhibitor (4S,5S,7S)-5-amino-N-butyl-7-[[4-tert-butyl-3-... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00102916 DAP001219 Approved Drug Aliskiren
CFAMM00103008 CHEMBL1807382 Bioactive (2S,4S,5S,7S)-5-amino-N-[3-(dimethylcarbamoylamino)-2,2-dimethylpropyl]-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide
CFAMM00103034 CHEMBL1808233 Bioactive (2S,4S,5S,7S)-5-amino-N-[3-(hexanoylamino)-2,2-dimethylpropyl]-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide
CFAMM00102967 CHEMBL537666 Bioactive SureCN7349369
CFAMM00102960 CHEMBL535632 Bioactive methyl 4-[[(2R,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-2,8-dimethylnonanoyl]amino]butanoate;hydrochloride
CFAMM00103033 CHEMBL1808232 Bioactive (2S,4S,5S,7S)-5-amino-N-[3-(2,2-dimethylpropanoylamino)-2,2-dimethylpropyl]-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide
CFAMM00102972 CHEMBL536296 Bioactive SureCN6044758
CFAMM00103032 CHEMBL1808231 Bioactive (2S,4S,5S,7S)-5-amino-N-[2,2-dimethyl-3-(3-methylbutanoylamino)propyl]-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide
CFAMM00102911 CHEMBL535855 Bioactive SureCN6044369
CFAMM00103012 CHEMBL1808227 Bioactive (2S,4S,5S,7S)-N-(3-acetamido-2,2-dimethylpropyl)-5-amino-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide
CFAMM00102905 CHEMBL536084 Bioactive SureCN7298279
CFAMM00102984 CHEMBL557357 Bioactive SureCN6044809
CFAMM00103031 CHEMBL1808230 Bioactive (2S,4S,5S,7S)-5-amino-N-[3-(butanoylamino)-2,2-dimethylpropyl]-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide
CFAMM00102958 CHEMBL537211 Bioactive SureCN7305291
CFAMM00102998 CHEMBL536993 Bioactive SureCN6044879
CFAMM00102991 CHEMBL541135 Bioactive SureCN7300385
CFAMM00102970 CHEMBL1667 Bioactive Aliskiren fumarate
CFAMM00102983 CHEMBL553943 Bioactive SureCN7307379
CFAMM00103010 CHEMBL1808229 Bioactive (2S,4S,5S,7S)-5-amino-N-[2,2-dimethyl-3-(propanoylamino)propyl]-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide
CFAMM00103003 CHEMBL1807384 Bioactive (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethylpropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide
CFAMM00102903 CHEMBL557016 Bioactive SureCN7307250
CFAMM00102982 CHEMBL540885 Bioactive SureCN7300882
CFAMM00102909 CHEMBL534505 Bioactive SureCN7346965
CFAMM00102962 CHEMBL556570 Bioactive SureCN6044503
CFAMM00103002 CHEMBL537876 Bioactive SureCN6044017
CFAMM00102928 CHEMBL559358 Bioactive Aliskiren hydrochloride
CFAMM00103028 CHEMBL1808235 Bioactive ethyl N-[3-[[(2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanoyl]amino]-2,2-dimethylpropyl]carbamate
CFAMM00102988 DNC000683 Investigative Drug Gelsolin

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27396 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543