Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283 5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680 Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44 Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397 Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30 Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140 Amine oxidase [flavin-containing] B Inhibitor Phenelzine Family 7 15 Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26 Noradrenergic re-uptake Inhibitor Phentermine Family 2 11 Squalene monooxygenase Inhibitor Naftifine Family 8 32 Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25 Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41 Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11 Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45 Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33 Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17 5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38 Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15 Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17 Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23 Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4 D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7 Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30 D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27 Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15 Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10 Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4 Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2 Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71 Amine oxidase [flavin-containing] A Inhibitor Trans-(+/-)-2-fl... 2 0 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1 Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0 Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6 Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9 Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13 Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1 Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2 Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1 Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 4 Sodium-dependent serotonin transporter Inhibitor 2-n-ethylamin... 14 5 Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2 D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0 Sigma non-opioid intracellular receptor 1 ligand 2-(3-iodophen... 2 0 Sigma non-opioid intracellular receptor 1 ligand AGN-PC-003L8Y... 2 4 Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0 Sodium-dependent serotonin transporter and Sodium-dependent no... 8 6 Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4 Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 5 5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0 Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4 Sodium-dependent serotonin transporter and Transporter inhibit... 7 2 Sodium-dependent serotonin transporter and Transporter inhibit... 7 2 C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0 Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0 Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2 Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0 Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0 Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1 Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1 1-benzyl-3,6-diazatricyclo[4.3.1.1~3,8~]undecan-9-amine NP ZIN... 2 1 1-[(E)-3-phenylprop-2-enyl]-4-[[(4S)-4-prop-1-en-2-ylcyclohexe... 1 1
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00103312 CHEMBL196626 Bioactive
SureCN4412259 CFAMM00103311 CHEMBL178124 Bioactive
AGN-PC-042EYA CFAMM00103304 CHEMBL194375 Bioactive
SureCN4406586 CFAMM00103284 CHEMBL152478 Bioactive
2-(3-fluorophenyl)-N-methyl-N-(2-pyrrolidin-1-ylethyl)ethanamine CFAMM00103303 CHEMBL381373 Bioactive
SureCN5995903 CFAMM00103316 CHEMBL544509 Bioactive
(E)-3-fluoro-2-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine;hydrochloride CFAMM00103296 CHEMBL207374 Bioactive
SureCN5993177 CFAMM00103309 CHEMBL443304 Bioactive
1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-7-(trifluoromethyl)- CFAMM00103302 CHEMBL134418 Bioactive
3-(4-fluorophenyl)-7-methyl-7-azabicyclo[2.2.1]heptane CFAMM00103295 CHEMBL372211 Bioactive
SureCN4405016 CFAMM00103301 CHEMBL153758 Bioactive
2-(4-fluorophenyl)-N-methyl-N-(2-pyrrolidin-1-ylethyl)ethanamine CFAMM00103313 CHEMBL365524 Bioactive
SureCN4685032 CFAMM00103293 CHEMBL174594 Bioactive
AGN-PC-075AKE CFAMM00103290 CHEMBL198987 Bioactive
SureCN4406657 CFAMM00103283 CHEMBL36059 Bioactive
AGN-PC-073JVH CFAMM00103315 CHEMBL451619 Bioactive
SureCN4489994 CFAMM00103308 CHEMBL209155 Bioactive
(3aS,4S,6aR)-4-[3-(trifluoromethyl)phenyl]-1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrole CFAMM00103314 CHEMBL2011565 Bioactive
4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine;hydrochloride CFAMM00103279 CHEMBL1813308 Bioactive
(3aR,7aS)-7a-(3,4-difluorophenyl)-2-methyl-3,3a,4,5,6,7-hexahydro-1H-isoindole CFAMM00103294 CHEMBL93682 Bioactive
SureCN7348015 CFAMM00103287 CHEMBL1683124 Bioactive
4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]-N-(4,4,4-trifluorobutyl)cyclohexan-1-amine CFAMM00103289 CHEMBL198986 Bioactive
SureCN4406514 CFAMM00103306 21461199 Patent Compound
AGN-PC-03B7IS CFAMM00103286 11736340 Patent Compound
4-[3-(trifluoromethyl)phenyl]piperidine CFAMM00103299 21686914 Patent Compound
AGN-PC-03EERM CFAMM00103285 14502067 Patent Compound
AGN-PC-001JWG CFAMM00103298 57258985 Patent Compound
AGN-PC-0BQI4Y CFAMM00103291 3956888 Patent Compound
2-[(4-phenylphenyl)methyl]pyrrolidine CFAMM00103317 15637616 Patent Compound
2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE] CFAMM00103310 485415 Patent Compound
Benzenemethanamine, N-ethyl-3-(trifluoromethyl)- CFAMM00103282 16788367 Patent Compound
N-(2-Amino-1-[3-(trifluoromethyl)phenyl]ethyl)-N,N-dimethylamine
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Dr.
Chen Yuzong Deputy
Director of Center for Computational Science and Engineering All rights reserved.
