CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD807
Family Name Serotonin re-uptake Inhibitor Dexfenfluramine Family
No. of Seeds 6 No. of Other Members 31
Family Centroid CFAMM00103307 Functional Category Approved Drug
Superfamily Biogenic amine receptor, re-uptake and enxyme binding amphetamine phenethylamine Superfamily
Class Class 73

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Amine oxidase [flavin-containing] B Inhibitor Phenelzine Family 7 15
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41
Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Amine oxidase [flavin-containing] A Inhibitor Trans-(+/-)-2-fl... 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 4
Sodium-dependent serotonin transporter Inhibitor 2-n-ethylamin... 14 5
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0
Sigma non-opioid intracellular receptor 1 ligand 2-(3-iodophen... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-003L8Y... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 8 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 5
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
1-benzyl-3,6-diazatricyclo[4.3.1.1~3,8~]undecan-9-amine NP ZIN... 2 1
1-[(E)-3-phenylprop-2-enyl]-4-[[(4S)-4-prop-1-en-2-ylcyclohexe... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00103297 DAP001478 Approved Drug Fenfluramine
CFAMM00103307 DAP001224 Approved Drug Dexfenfluramine
CFAMM00103288 DNC012539 Investigative Drug 3-(3,5-Dimethyl-phenyl)-piperidine
CFAMM00103300 DNC012089 Investigative Drug 1-Propyl-3-(3-trifluoromethyl-phenyl)-pyrrolidine
CFAMM00103292 DNC012555 Investigative Drug 3-(2,3-Dimethyl-phenyl)-piperidine
CFAMM00103305 DNC014149 Investigative Drug 3-(4-Trifluoromethylphenyl)-2-nortropene

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48716 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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