Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.
Cousin Family Names Seeds Members Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283 5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680 Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44 Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397 Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30 Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140 Amine oxidase [flavin-containing] B Inhibitor Phenelzine Family 7 15 Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26 Noradrenergic re-uptake Inhibitor Phentermine Family 2 11 Squalene monooxygenase Inhibitor Naftifine Family 8 32 Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25 Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41 Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11 Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45 Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33 Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17 5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38 Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15 Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17 Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23 Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4 D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7 Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30 D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27 Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15 Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10 Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4 Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2 Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71 Amine oxidase [flavin-containing] A Inhibitor Trans-(+/-)-2-fl... 2 0 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1 Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0 Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6 Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9 Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13 Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1 Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2 Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1 Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 4 Sodium-dependent serotonin transporter Inhibitor 2-n-ethylamin... 14 5 Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2 D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0 Sigma non-opioid intracellular receptor 1 ligand 2-(3-iodophen... 2 0 Sigma non-opioid intracellular receptor 1 ligand AGN-PC-003L8Y... 2 4 Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0 Sodium-dependent serotonin transporter and Sodium-dependent no... 8 6 Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4 Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 5 5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0 Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4 Sodium-dependent serotonin transporter and Transporter inhibit... 7 2 Sodium-dependent serotonin transporter and Transporter inhibit... 7 2 C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0 Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0 Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2 Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0 Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0 Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1 Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1 1-benzyl-3,6-diazatricyclo[4.3.1.1~3,8~]undecan-9-amine NP ZIN... 2 1 1-[(E)-3-phenylprop-2-enyl]-4-[[(4S)-4-prop-1-en-2-ylcyclohexe... 1 1
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00103284
CHEMBL152478
Bioactive
2-(3-fluorophenyl)-N-methyl-N-(2-pyrrolidin-1-ylethyl)ethanamine CFAMM00103303
CHEMBL381373
Bioactive
SureCN5995903 CFAMM00103316
CHEMBL544509
Bioactive
(E)-3-fluoro-2-[3-(trifluoromethyl)phenyl]prop-2-en-1-amine;hydrochloride CFAMM00103296
CHEMBL207374
Bioactive
SureCN5993177 CFAMM00103309
CHEMBL443304
Bioactive
1,5-Methano-1H-3-benzazepine, 2,3,4,5-tetrahydro-7-(trifluoromethyl)- CFAMM00103302
CHEMBL134418
Bioactive
3-(4-fluorophenyl)-7-methyl-7-azabicyclo[2.2.1]heptane CFAMM00103295
CHEMBL372211
Bioactive
SureCN4405016 CFAMM00103301
CHEMBL153758
Bioactive
2-(4-fluorophenyl)-N-methyl-N-(2-pyrrolidin-1-ylethyl)ethanamine CFAMM00103313
CHEMBL365524
Bioactive
SureCN4685032 CFAMM00103312
CHEMBL196626
Bioactive
SureCN4412259 CFAMM00103311
CHEMBL178124
Bioactive
AGN-PC-042EYA CFAMM00103304
CHEMBL194375
Bioactive
SureCN4406586 CFAMM00103290
CHEMBL198987
Bioactive
SureCN4406657 CFAMM00103283
CHEMBL36059
Bioactive
AGN-PC-073JVH CFAMM00103315
CHEMBL451619
Bioactive
SureCN4489994 CFAMM00103308
CHEMBL209155
Bioactive
(3aS,4S,6aR)-4-[3-(trifluoromethyl)phenyl]-1,2,3,3a,4,5,6,6a-octahydrocyclopenta[c]pyrrole CFAMM00103314
CHEMBL2011565
Bioactive
4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine;hydrochloride CFAMM00103279
CHEMBL1813308
Bioactive
(3aR,7aS)-7a-(3,4-difluorophenyl)-2-methyl-3,3a,4,5,6,7-hexahydro-1H-isoindole CFAMM00103294
CHEMBL93682
Bioactive
SureCN7348015 CFAMM00103287
CHEMBL1683124
Bioactive
4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]-N-(4,4,4-trifluorobutyl)cyclohexan-1-amine CFAMM00103293
CHEMBL174594
Bioactive
AGN-PC-075AKE CFAMM00103289
CHEMBL198986
Bioactive
SureCN4406514 CFAMM00103317
15637616
Patent Compound
2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE] CFAMM00103310
485415
Patent Compound
Benzenemethanamine, N-ethyl-3-(trifluoromethyl)- CFAMM00103282
16788367
Patent Compound
N-(2-Amino-1-[3-(trifluoromethyl)phenyl]ethyl)-N,N-dimethylamine CFAMM00103306
21461199
Patent Compound
AGN-PC-03B7IS CFAMM00103286
11736340
Patent Compound
4-[3-(trifluoromethyl)phenyl]piperidine CFAMM00103299
21686914
Patent Compound
AGN-PC-03EERM CFAMM00103285
14502067
Patent Compound
AGN-PC-001JWG CFAMM00103298
57258985
Patent Compound
AGN-PC-0BQI4Y CFAMM00103291
3956888
Patent Compound
2-[(4-phenylphenyl)methyl]pyrrolidine
Statistics of CFAM Database
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
48716 visits since 2014 .........
Dr.
Chen Yuzong
Deputy
Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore
All rights reserved.