CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Thymidylate synthase Inhibitor Leucovorin/5-fluorouracil Family
No. of Seeds 9 No. of Other Members 83
Family Centroid CFAMM00103497 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Thymidylate synthase Inhibitor Leucovorin/5-fluorouracil Superfamily
Class Class 617

Cousin Family NamesSeedsMembers
Thymidylate synthase Inhibitor Raltitrexed Family 1 15
Dihydroorotase, putative Inhibitor 5-amino Orotate Family 2 4
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Trifunctional purine biosynthetic protein adenosine-3 Inhibito... 2 1
Integrin alpha-V and Integrin beta-3 Inhibitor Cyclo-[-arg-gly... 5 38
Integrin beta-3 Inhibitor DMP-728 Family 3 0
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Estrogen receptor and Thymidylate synthase ligand (2R)-2-[[(4S... 1 1
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-037CNR f... 5 8
Glycogen phosphorylase, liver form inhibitor SureCN5195475 family 9 5
Glycogen phosphorylase, liver form inhibitor AGN-PC-00CDLB family 2 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-2-[[(2S)... 1 1
Transmembrane protease serine 11D and Suppressor of tumorigeni... 1 3
Pteridines and Derivatives Metabolite 7,8-Dihydropteroic acid ... 1 0


External ID

Functional Category

Molecule Name

CFAMM00103526 DAP001308 Approved Drug Tetrahydrofolic acid
CFAMM00103497 DAP001244 Approved Drug Leucovorin/5-fluorouracil
CFAMM00103459 DNCL003765 Clinical Trial Drug Levoleucovorin
CFAMM00103516 DNC003050 Investigative Drug 5,10-Methylene-6-Hydrofolic Acid
CFAMM00103472 DNC002547 Investigative Drug 10-Propargyl-5,8-Dideazafolic Acid
CFAMM00103552 DNC003183 Investigative Drug Dihydrofolic Acid
CFAMM00103545 DNC007311 Investigative Drug PDDF
CFAMM00103474 DNC012763 Investigative Drug DIDEAZAFOLATE
CFAMM00103453 DNC003164 Investigative Drug 5-Formyl-6-Hydrofolic Acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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