CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD82
Family Name Beta adrenergic receptor ligand naphthol derivative Propranolol family
No. of Seeds 11 No. of Other Members 218
Family Centroid CFAMM00016911 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Adrenergic receptor ligand Propranolol Levobunolol Metipranolol Superfamily
Class Class 80

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta adrenergic receptor Ligand Metipranolol Family 5 1
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Extracellular calcium-sensing receptor Ligand Ronacaleret Family 2 9
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Beta-3 adrenergic receptor Ligand Amibegron Family 8 46
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Vernakalant family 1 1
Acolbifene family 10 115
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 Ligand Al... 2 3
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Beta-3 adrenergic receptor Ligand ZD7114 Family 1 4
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Extracellular calcium-sensing receptor and Potassium voltage-g... 3 11
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Renin Inhibitor Ro-65-7219 Family 10 8
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Tubulin beta chain Inhibitor Colchinol Family 3 109
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
Leukotriene A-4 hydrolase inhibitor SureCN13809114 family 2 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Extracellular calcium-sensing receptor and Sodium-dependent no... 2 2
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Squalene synthase inhibitor 3-[4-[[(E)-ethylideneamino]oxymeth... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 2 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 12 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
5-hydroxytryptamine receptor 1A ligand oxalic acid;(1R,5S)-5-[... 2 0
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 1 0
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 1 0
Transporter and Sodium-dependent serotonin transporter inhibit... 1 5
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
Cathepsin B and Cathepsin S inhibitor (4S,5R)-4-(2,3-dimethylp... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 5
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 0
Sodium-dependent noradrenaline transporter and Cytochrome P450... 11 2
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Extracellular calcium-sensing receptor ligand SureCN4609584 fa... 7 8
Muscleblind-like protein 1 and Ferritin light chain inhibitor ... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Beta-1 adrenergic receptor ligand N-[2-[[(2S)-3-(2-cyanophenox... 1 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 3
Cytochrome P450 2D6 and Sodium channel protein type 1 subunit ... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00016911 DAP000089 Approved Drug Propranolol
CFAMM00016730 DAP000122 Approved Drug Nadolol
CFAMM00016820 CHEMBL1137 Bioactive 4-Hydroxypropranolol
CFAMM00016869 CHEMBL1671 Bioactive Propranolol hydrochloride
CFAMM00016720 CHEMBL69635 Bioactive (1S)-2-naphthalen-1-yloxy-1-[(2R)-piperidin-2-yl]ethanol
CFAMM00016852 CHEMBL287651 Bioactive 1-(2-methylpropylamino)-3-naphthalen-1-yloxypropan-2-ol
CFAMM00016898 CHEMBL19770 Bioactive 1-(tert-butylamino)-3-naphthalen-2-yloxybutan-2-ol
CFAMM00016719 CHEMBL302339 Bioactive (1S)-2-naphthalen-2-yloxy-1-[(2S)-piperidin-2-yl]ethanol
CFAMM00016751 CHEMBL304344 Bioactive (1S)-2-naphthalen-1-yloxy-1-[(2S)-piperidin-2-yl]ethanol
CFAMM00016750 CHEMBL287242 Bioactive ethyl 3-[(2-hydroxy-3-naphthalen-1-yloxypropyl)amino]propanoate
CFAMM00016782 DNC000002 Investigative Drug (-)-propranolol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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