CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD822
Family Name Type-1 angiotensin II receptor Ligand Forasartan Family
No. of Seeds 3 No. of Other Members 253
Family Centroid CFAMM00104083 Functional Category Approved Drug
Superfamily angiotensin II receptor ligand Forasartan Tasosartan Superfamily
Class Class 195

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
HER Inhibitor AC480 Family 4 67
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Gamma-aminobutyric acid A receptor Ligand Ocinaplon Family 1 10
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
SCH-900776 family 8 14
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Type-2 angiotensin II receptor Ligand SC-50560 Family 3 84
Type-2 angiotensin II receptor Ligand SC-55634 Family 8 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Xanthine dehydrogenase/oxidase inhibitor AGN-PC-06VJIZ family 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-met... 7 12
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Transient receptor potential cation channel subfamily V member... 1 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
Histamine H3 receptor ligand SureCN4025673 family 4 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
C-X-C chemokine receptor type 4 and Envelope glycoprotein gp16... 2 2
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 4 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Type-1B angiotensin II receptor ligand 2-[2-butyl-3-[[4-[2-(2H... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Serine/threonine-protein kinase Chk1 and Cyclin-A2 inhibitor S... 1 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 9 3
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Type-1 angiotensin II receptor and Peroxisome proliferator-act... 6 0
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 8-... 6 2
Vasopressin V1a receptor ligand 2-[4-[4-[(3-chlorophenyl)methy... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 5
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Metabotropic glutamate receptor 2 ligand 3-(cyclopropylmethyl)... 1 1
Scavenger receptor class B member 1 ligand 9-[3-(4,6-diethylpy... 2 0
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Type-1 angiotensin II receptor ligand 5-[2-[4-[[4-butyl-3-[[4-... 4 2
Motilin receptor ligand SureCN2004322 family 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
ALK tyrosine kinase receptor ligand 3-[1-[(3-fluorophenyl)meth... 2 0
Methionine aminopeptidase 2 inhibitor SureCN5373581 family 6 0
D(3) dopamine receptor and Muscarinic acetylcholine receptor M... 8 2
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-met... 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-(1,2,4-triazol... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 2
Type-1B angiotensin II receptor and Type-1 angiotensin II rece... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 9 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 5 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 5
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... 5 3
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Type-1B angiotensin II receptor ligand SureCN9309010 family 5 1
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 3 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Fatty-acid amide hydrolase 1 and Liver carboxylesterase 1 inhi... 1 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Mitogen-activated protein kinase 8 inhibitor N-[4-[4-[2-(cyclo... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 9 0
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... 1 0
Type-1B angiotensin II receptor and Type-2 angiotensin II rece... 1 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00104083 DAP001256 Approved Drug Forasartan
CFAMM00104101 DNC014302 Investigative Drug 3,5-bis(2-methylpyridin-4-yl)-1H-1,2,4-triazole
CFAMM00104096 DNC012785 Investigative Drug SC-52892

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24336 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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