CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Type-1 angiotensin II receptor Ligand Tasosartan Family
No. of Seeds 10 No. of Other Members 29
Family Centroid CFAMM00104217 Functional Category Approved Drug
Superfamily angiotensin II receptor ligand Forasartan Tasosartan Superfamily
Class Class 195

Cousin Family NamesSeedsMembers
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Histamine H4 receptor Ligand A-943931 Family 14 11
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Smoothened homolog inhibitor SureCN1091571 family 2 2
Type-1 angiotensin II receptor ligand SureCN9527437 family 2 34
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Type-1 angiotensin II receptor and Cytochrome P450 2C19 ligand... 2 1
3-phosphoinositide-dependent protein kinase 1 and Rho-associat... 12 11
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 7
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 4 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-met... 2 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 35 14
Type-1B angiotensin II receptor and Type-1 angiotensin II rece... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 5
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Type-1B angiotensin II receptor ligand SureCN9309010 family 5 1
Aurora kinase A inhibitor SureCN2205392 family 2 2


External ID

Functional Category

Molecule Name

CFAMM00104217 DAP001258 Approved Drug Tasosartan
CFAMM00104208 CHEMBL348472 Bioactive 4-methyl-2-propan-2-yl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
CFAMM00104244 CHEMBL152957 Bioactive 2-methyl-4-propyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
CFAMM00104221 CHEMBL135309 Bioactive SureCN684181
CFAMM00104249 CHEMBL440731 Bioactive 2,4,6,6-tetramethyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5H-pyrido[2,3-d]pyrimidin-7-one
CFAMM00104226 CHEMBL345528 Bioactive SureCN8803987
CFAMM00104240 CHEMBL152958 Bioactive 4-ethyl-2-methyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
CFAMM00104232 CHEMBL153188 Bioactive AGN-PC-00F9R4
CFAMM00104248 CHEMBL150507 Bioactive 2-ethyl-4-methyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[2,3-d]pyrimidin-7-one
CFAMM00104247 CHEMBL337067 Bioactive SureCN7426784

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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