CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD84
Family Name Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family
No. of Seeds 48 No. of Other Members 78
Family Centroid CFAMM00017161 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Superfamily
Class Class 82

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Serine/threonine-protein kinase PLK1 Inhibitor HMN-214 Family 3 58
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Apricoxib family 8 77
Indeglitazar family 3 39
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Integrin beta-3 Inhibitor L-756568 Family 8 59
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 2 0
Collagenase 3 and A disintegrin and metalloproteinase with thr... 5 6
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Macrophage metalloelastase inhibitor (2S)-3-methyl-2-[[8-[3-(t... 2 6
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
5-hydroxytryptamine receptor 6 ligand SureCN5253197 family 4 2
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Peroxisome proliferator-activated receptor gamma ligand NSI fa... 5 3
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 5 2
Endothelin-1 receptor and Endothelin B receptor ligand AGN-PC-... 11 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Cysteinyl leukotriene receptor 1 ligand 1-[[4-[(2-chlorophenyl... 4 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 3 3
Prostaglandin E2 receptor EP3 subtype ligand (E)-3-(1-methyl-4... 14 12
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 5
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 2
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 1 6
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Pol polyprotein inhibitor Phenprocoumon IndolEtCONH deriv. family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00017161 DAP000091 Approved Drug Zafirlukast
CFAMM00017071 CHEMBL286827 Bioactive 3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methyl-N-[2-(trifluoromethyl)hexyl]indole-5-carboxamide
CFAMM00017099 CHEMBL281066 Bioactive N-(2-ethylbutyl)-3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methylindole-5-carboxamide
CFAMM00017086 CHEMBL49566 Bioactive SureCN4452125
CFAMM00017194 CHEMBL25841 Bioactive 3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluorobutyl)indole-5-carboxamide
CFAMM00017142 CHEMBL24613 Bioactive AGN-PC-0032WL
CFAMM00017156 CHEMBL300846 Bioactive SureCN8951644
CFAMM00017185 CHEMBL1048 Bioactive N-DEALKYLATED DERIVATIVE
CFAMM00017133 CHEMBL24505 Bioactive 3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methyl-N-[4,4,4-trifluoro-3-(trifluoromethyl)butyl]indole-5-carboxamide
CFAMM00017085 CHEMBL79479 Bioactive cyclopentyl N-[1-[2-(dimethylamino)ethylcarbamoyl]-3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]indol-5-yl]carbamate
CFAMM00017111 CHEMBL284322 Bioactive 1-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-N-(4,4,4-trifluoro-2-methylbutyl)indole-6-carboxamide
CFAMM00017091 CHEMBL26617 Bioactive 1-ethyl-3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-N-(4,4,4-trifluoro-2-methylbutyl)indole-5-carboxamide
CFAMM00017141 CHEMBL26332 Bioactive 3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylidenebutyl)indole-5-carboxamide
CFAMM00017168 CHEMBL24256 Bioactive SureCN10469555
CFAMM00017118 CHEMBL51289 Bioactive 4-[[1-[(3-cyanophenyl)methyl]-5-[(2-cyclopentylacetyl)amino]indol-3-yl]methyl]-3-methoxy-N-methylsulfonylbenzamide
CFAMM00017132 CHEMBL24506 Bioactive 3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methyl-N-[[1-(2,2,2-trifluoroethyl)cyclopropyl]methyl]indole-5-carboxamide
CFAMM00017147 CHEMBL311868 Bioactive SureCN8166124
CFAMM00017084 CHEMBL26384 Bioactive 3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2,2-dimethylbutyl)indole-5-carboxamide
CFAMM00017097 CHEMBL286885 Bioactive 3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methyl-N-[(Z)-4,4,4-trifluoro-2-methylbut-2-enyl]indole-5-carboxamide
CFAMM00017191 CHEMBL26284 Bioactive 3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-3-methylbutyl)indole-5-carboxamide
CFAMM00017125 CHEMBL48927 Bioactive SureCN4466998
CFAMM00017140 CHEMBL297952 Bioactive N-(2-chlorophenyl)sulfonyl-4-[[5-[(2-cyclopentylacetyl)amino]-1-methylindol-3-yl]methyl]-3-methoxybenzamide
CFAMM00017090 CHEMBL79741 Bioactive cyclopentyl N-[3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-(3-phenylpropylcarbamoyl)indol-5-yl]carbamate
CFAMM00017183 CHEMBL79952 Bioactive SureCN8166270
CFAMM00017068 CHEMBL24652 Bioactive SureCN157377
CFAMM00017131 CHEMBL431348 Bioactive SureCN4466431
CFAMM00017109 CHEMBL51891 Bioactive SureCN13983259
CFAMM00017124 CHEMBL78141 Bioactive SureCN8161233
CFAMM00017139 CHEMBL51239 Bioactive 4-[[1-[(3-cyanophenyl)methyl]-5-[(2-cyclopentylacetyl)amino]indol-3-yl]methyl]-3-methoxy-N-propan-2-ylsulfonylbenzamide
CFAMM00017180 CHEMBL412056 Bioactive cyclopentyl N-[3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methylindazol-5-yl]carbamate
CFAMM00017102 CHEMBL301616 Bioactive N-(2-bromophenyl)sulfonyl-4-[[5-[(2-cyclopentylacetyl)amino]-1-methylindol-3-yl]methyl]-3-methoxybenzamide
CFAMM00017159 CHEMBL26080 Bioactive 3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methyl-N-[(3,3,4,4-tetrafluorocyclopentyl)methyl]indole-5-carboxamide
CFAMM00017095 CHEMBL176286 Bioactive 1-ethyl-3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-N-[2-(trifluoromethyl)butyl]indole-5-carboxamide
CFAMM00017123 CHEMBL78140 Bioactive SureCN8423162
CFAMM00017137 CHEMBL25819 Bioactive 3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-propyl-N-(4,4,4-trifluoro-2-methylbutyl)indole-5-carboxamide
CFAMM00017152 CHEMBL48435 Bioactive SureCN4456175
CFAMM00017115 CHEMBL301498 Bioactive N-(benzenesulfonyl)-4-[[5-(cyclopentylcarbamoylamino)-1-methylindol-3-yl]methyl]-3-methoxybenzamide
CFAMM00017158 CHEMBL50370 Bioactive SureCN4468802
CFAMM00017144 CHEMBL24596 Bioactive 1-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-3-methyl-N-(4,4,4-trifluoro-2-methylbutyl)indole-6-carboxamide
CFAMM00017171 CHEMBL12985 Bioactive N-(2-ethyl-4,4,4-trifluorobutyl)-3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methylindole-5-carboxamide
CFAMM00017121 CHEMBL83166 Bioactive cyclopentyl N-[3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-(morpholine-4-carbonyl)indol-5-yl]carbamate
CFAMM00017073 CHEMBL79366 Bioactive SureCN8429364
CFAMM00017151 CHEMBL24758 Bioactive 3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methyl-N-[(2S)-4,4,4-trifluoro-2-methylbutyl]indole-5-carboxamide
CFAMM00017164 CHEMBL442263 Bioactive Masilukast
CFAMM00017195 CHEMBL313567 Bioactive SureCN8161225
CFAMM00017114 CHEMBL51580 Bioactive N-(2-chlorophenyl)sulfonyl-4-[[5-(cyclopentylcarbamoylamino)-1-methylindol-3-yl]methyl]-3-methoxybenzamide
CFAMM00017128 CHEMBL52492 Bioactive N-(benzenesulfonyl)-4-[[5-(cyclopentylcarbamoylamino)-1-propylindol-3-yl]methyl]-3-methoxybenzamide
CFAMM00017065 CHEMBL310446 Bioactive cyclopentyl N-[1-(diethylcarbamoyl)-3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]indol-5-yl]carbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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