CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD856
Family Name Bacterial outer membrane Inhibitor Daptomycin Family
No. of Seeds 6 No. of Other Members 50
Family Centroid CFAMM00108746 Functional Category Approved Drug with Natural Product
Superfamily Bacterial outer membrane Inhibitor Daptomycin Superfamily
Class Class 647

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Alpha adrenergic receptor ligand ergot alkaloid Dihydroergota... 7 12
Gonadotropin-releasing hormone receptor Ligand decapeptide ana... 9 162
Epidermal Growth Factor family 111 209
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
HIV-1 protease Inhibitor Atazanavir Family 16 58
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
NS5A protein Inhibitor Bms 790052 Family 5 9
CBP-501 family 7 8
CP-18770 family 6 27
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Renin Inhibitor Enalkiren Family 56 44
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Cholecystokinin receptor type A ligand A-65186 family 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydr... 2 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 0
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... 3 4
Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-... 3 0
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 4 0
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Prothrombin and Trypsin-1 inhibitor 1-[2-(4-benzylpiperidin-1-... 2 2
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[2-(1H-ind... 1 0
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Relaxin-3 receptor 1 and Relaxin-3 receptor 2 ligand CHEMBL203... 4 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 4
Gonadotropin-releasing hormone receptor ligand (3S)-3-[[(2R)-2... 1 0
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Gonadotropin-releasing hormone receptor ligand (3S)-3-[[(2S)-2... 5 0
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Protein kinase C delta type and Protein kinase C beta type inh... 4 4
Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R... 17 10
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Growth factor receptor-bound protein 2 ligand 2-[4-[(2S)-3-[[1... 1 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Gastrin/cholecystokinin type B receptor ligand (2R)-2-[[5-(8-a... 2 3
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Neprilysin and Endothelin-converting enzyme 1 inhibitor (2S)-2... 5 0
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Renin inhibitor tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4... 2 2
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 9 3
KiSS-1 receptor ligand SureCN5132924 family 2 4
Angiotensin-converting enzyme inhibitor AC1L1IZN family 2 2
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
Angiotensin-converting enzyme and Endothelin-converting enzyme... 1 0
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Interstitial collagenase and Stromelysin-1 inhibitor CHEMBL887... 1 0
Substance-P receptor ligand methyl 6-acetamido-3-[[(2S)-1-[[3,... 1 0
Melanocortin receptor 4 and Melanocortin receptor 5 ligand CHE... 1 1
Neprilysin inhibitor AGN-PC-073PUZ family 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 48
Prostaglandin D2 receptor 2 ligand AGN-PC-00QBAU family 1 24
Calcium/calmodulin-dependent protein kinase type II subunit de... 1 0
5-(carbamoylamino)pentanoate NP ZINC12297125 Family 8 0
NP Agn-pc-099dao Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00108746 DAP001328 Approved Drug Daptomycin
CFAMM00108699 CHEMBL1790866 Bioactive methyl (2S)-2-[[(2S,3R)-2-[[1-[(2R,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-4-amino-4-oxobutanoyl]amino]-2-hydroxy-4-phenylbutyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoate
CFAMM00108714 DCL000894 Clinical Trial Drug Nepadutant
CFAMM00108721 DNC006638 Investigative Drug PLSQETFSDLWKLLPEN-NH2
CFAMM00108698 DNC008062 Investigative Drug FR-901451
CFAMM00108690 DNC001098 Investigative Drug PD142893

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26190 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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