CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD866
Family Name Peptide deformylase, mitochondrial inhibitor folic acid analog Aminopterin Family
No. of Seeds 59 No. of Other Members 98
Family Centroid CFAMM00108942 Functional Category Approved Drug
Superfamily Folate receptor, Peptide deformylase binding Folic Acid analogs Superfamily
Class Class 639

Cousin Family NamesSeedsMembers
Thymidylate synthase inhibitor pyrrotopyrimidine derivative Pe... 4 23
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Folate receptor gamma Ligand Folic Acid Family 4 100
Prothrombin Inhibitor Dabigatran Family 7 182
Thromboxane A2 receptor Ligand Bibv 308 Family 14 40
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Integrin alpha-4 Inhibitor CDP323 Family 8 17
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
BIBT986 family 7 96
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
GDC-0349 family 44 77
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(3,5... 28 18
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 11
Dihydrofolate reductase inhibitor 10-Oxaaminopterin family 1 2
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Thymidylate synthase inhibitor (2R)-2-[[(4S)-4-carboxy-4-[[4-[... 55 43
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 6 2
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 11
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Platelet-activating factor receptor ligand 5-methyl-2-[4-(2-me... 1 2
Transient receptor potential cation channel subfamily V member... 1 4
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Thymidylate synthase inhibitor AC1LAB82 family 17 0
Integrin alpha-4 inhibitor AC1O7HJM family 3 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-di... 3 1
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Dihydrofolate reductase and Trifunctional purine biosynthetic ... 1 6
Thymidylate synthase inhibitor AGN-PC-0757PM family 1 0
Cannabinoid receptor 2 ligand AGN-PC-0A9SMV family 1 1
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Caspase-1 inhibitor (3S)-4-oxo-3-[[6-[[4-(quinoxalin-2-ylamino... 5 6
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(2,6-di... 6 5
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-methyl-4... 15 14
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Aurora kinase A inhibitor Bisanilinopyrimidine, 6i family 1 0
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 1
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Integrin beta-1 and Integrin alpha-4 inhibitor (5R)-5-[[(2R)-2... 2 3
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(1-propan-2-ylpyr... 5 6
Coagulation factor VII inhibitor 2-[2-[(1-aminoisoquinolin-6-y... 1 14
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Folylpolyglutamate synthase, mitochondrial and Dihydrofolate r... 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5368289 f... 4 5
Dihydrofolate reductase inhibitor AGN-PC-073PND family 4 0
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Folate receptor alpha and Trifunctional purine biosynthetic pr... 9 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5370042 f... 8 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5367895 f... 3 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Integrin alpha-4 inhibitor (2S)-2-[(2-bromo-3-oxospiro[3.5]non... 9 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Collagenase 3 inhibitor MMP-13 Inhibitor family 1 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-(2-aminoethyl)pipe... 17 2
P2Y purinoceptor 12 inhibitor (4S)-4-[[6-[4-[2-(methylamino)-2... 51 8
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
P2Y purinoceptor 12 inhibitor pentyl 4-[(2S)-5-[(2-methylpropa... 18 0
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-3-[4-[4-[[... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 1 1
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-(4-amino-... 2 3
Thymidylate synthase and Dihydrofolate reductase inhibitor (2S... 1 0
Platelet-activating factor receptor ligand SureCN7869540 family 1 2
NP Agn-pc-05rdcq Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00109032 DAP001549 Approved Drug Pralatrexate
CFAMM00108942 DAP001346 Approved Drug Aminopterin
CFAMM00109043 CHEMBL2051987 Bioactive (2S)-2-[[4-[(2R)-1-(2,4-diaminopteridin-6-yl)propan-2-yl]benzoyl]amino]pentanedioic acid
CFAMM00109036 CHEMBL428862 Bioactive AGN-PC-00O78Y
CFAMM00108973 CHEMBL10515 Bioactive AGN-PC-00PPKV
CFAMM00108940 CHEMBL7382 Bioactive 2-[[2-carboxy-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]ethyl]carbamoylamino]pentanedioic acid
CFAMM00108953 CHEMBL35427 Bioactive 2-[[4-[5-carboxypentyl-[(2,4-diaminopteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid
CFAMM00109014 CHEMBL154152 Bioactive AGN-PC-075UC2
CFAMM00109042 CHEMBL11610 Bioactive 2-[[4-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl-ethylamino]benzoyl]amino]pentanedioic acid
CFAMM00108992 CHEMBL35364 Bioactive AGN-PC-00PJNU
CFAMM00108911 CHEMBL440857 Bioactive AC1L8NY7
CFAMM00108985 CHEMBL308279 Bioactive NSC654830
CFAMM00109000 CHEMBL166915 Bioactive 82318-25-0
CFAMM00108965 CHEMBL293546 Bioactive (2S)-2-[[4-carboxy-4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]butanoyl]amino]butanedioic acid
CFAMM00108945 CHEMBL335716 Bioactive AGN-PC-075LPJ
CFAMM00109019 CHEMBL56533 Bioactive n2-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-n-methylglutamine
CFAMM00109034 CHEMBL284360 Bioactive NSC302057
CFAMM00108924 CHEMBL112061 Bioactive AGN-PC-074YML
CFAMM00108999 CHEMBL132431 Bioactive NSC174121
CFAMM00108964 CHEMBL307486 Bioactive SureCN14314
CFAMM00108977 CHEMBL20428 Bioactive AGN-PC-00PPKX
CFAMM00108983 CHEMBL12094 Bioactive 2-[[4-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
CFAMM00108902 CHEMBL160699 Bioactive AGN-PC-003DQ4
CFAMM00108963 CHEMBL224946 Bioactive (2S)-2-[6-[(2,4-diaminopteridin-6-yl)methyl-methylamino]-3-oxo-1H-isoindol-2-yl]pentanedioic acid
CFAMM00109039 CHEMBL354055 Bioactive NSC324062
CFAMM00108930 CHEMBL349572 Bioactive (2R,4R)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-4-fluoropentanedioic acid
CFAMM00108943 CHEMBL284943 Bioactive AGN-PC-073K9W
CFAMM00108908 CHEMBL65616 Bioactive AGN-PC-002IVR
CFAMM00109023 CHEMBL306438 Bioactive AGN-PC-01USLZ
CFAMM00108914 CHEMBL52715 Bioactive NSC294902
CFAMM00108975 CHEMBL293147 Bioactive (2S)-2-[[4-carboxy-4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]butanoyl]amino]pentanedioic acid
CFAMM00108988 CHEMBL160505 Bioactive FMTX
CFAMM00108929 CHEMBL33045 Bioactive (4R)-4-amino-5-[[4-[[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)amino]methyl]benzoyl]amino]-5-oxopentanoic acid
CFAMM00109016 CHEMBL155016 Bioactive 66147-31-7
CFAMM00108955 CHEMBL55775 Bioactive NSC269399
CFAMM00108968 CHEMBL275309 Bioactive n-(4-{[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methyl]amino}benzoyl)glutamic acid
CFAMM00108996 CHEMBL7684 Bioactive NSC324063
CFAMM00108948 CHEMBL72898 Bioactive AGN-PC-074GXQ
CFAMM00109037 CHEMBL307820 Bioactive AGN-PC-002IVU
CFAMM00108900 CHEMBL114733 Bioactive AGN-PC-074YND
CFAMM00108987 CHEMBL55590 Bioactive 71074-44-7
CFAMM00108912 DNC000414 Investigative Drug CH4474
CFAMM00108927 DNC007688 Investigative Drug methotrexate gamma-hydroxamic acid
CFAMM00109007 DNC000933 Investigative Drug Methotrexate
CFAMM00109018 DNC007650 Investigative Drug methotrexate gamma-L-phenylalaninehydroxamic acid
CFAMM00109010 DNC011516 Investigative Drug GNF-PF-173
CFAMM00108921 DNC007687 Investigative Drug methotrexate gamma-L-proline-hydroxamic acid
CFAMM00108981 DNC000592 Investigative Drug Edatrexate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26853 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543