CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD867
Family Name Histamine H1 receptor Ligand Antazoline Family
No. of Seeds 5 No. of Other Members 57
Family Centroid CFAMM00109105 Functional Category Approved Drug
Superfamily Histamine H1 receptor Ligand Antazoline Superfamily
Class Class 655

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Histamine H1 receptor Ligand Epinastine Family 2 26
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
NMDA receptor Ligand Aptiganel Hcl Family 2 82
5-hydroxytryptamine receptor 5A Ligand N,4-dimethyl-3,4-dihydr... 8 51
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3,... 3 4
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
5-hydroxytryptamine receptor 6 Ligand [2-(3h-indol-1-yl)-ethyl... 2 7
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 2 9
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Sphingosine kinase 2 Inhibitor (r)-2-amino-3-(4-octylphenylami... 1 16
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 13
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
Sigma non-opioid intracellular receptor 1 and Glutamate recept... 1 0
Sigma non-opioid intracellular receptor 1 and Glutamate recept... 2 1
Nitric oxide synthase, brain inhibitor N'-[3-(aminomethyl)phen... 2 6
ATP-binding cassette sub-family C member 9 and ATP-sensitive i... 1 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0
Squalene monooxygenase inhibitor 3-[[[(E)-6,6-dimethylhept-2-e... 1 0
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 1 1
Trypanothione reductase inhibitor 6-bromo-2-methyl-4-phenyl-3-... 2 3
Cytochrome P450 2C9 and Cytochrome P450 2D6 inhibitor N'-(4-he... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00109110 DAP001365 Approved Drug Antazoline hydrochloride
CFAMM00109080 DAP001373 Approved Drug Antazoline phosphate
CFAMM00109105 DAP001347 Approved Drug Antazoline
CFAMM00109089 CHEMBL51131 Bioactive AGN-PC-00L0BF
CFAMM00109100 CHEMBL300628 Bioactive AGN-PC-00L0BH

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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