CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Gonadotropin-releasing hormone receptor Ligand decapeptide analog Cetrorelix Family
No. of Seeds 9 No. of Other Members 162
Family Centroid CFAMM00017365 Functional Category Approved Drug
Superfamily Gonadotropin-releasing hormone receptor Ligand Cetrorelix Superfamily
Class Class 85

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Epidermal Growth Factor family 111 209
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Insulin receptor Ligand Insulin, Porcine Family 61 205
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Gonadotropin-releasing hormone Inhibitor ASP3550 Family 33 60
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Gonadotropin-releasing hormone receptor Ligand Azaline B Family 12 0
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Gonadotropin-releasing hormone receptor Ligand [d-ncy(methyl)4... 32 0
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Endothelin B receptor Ligand IRL-2500 Family 34 87
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
KiSS-1 receptor ligand (2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-... 3 0
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2


External ID

Functional Category

Molecule Name

CFAMM00017362 DAP001386 Approved Drug Ganirelix
CFAMM00017365 DAP000096 Approved Drug Cetrorelix
CFAMM00017363 DAP000094 Approved Drug Abarelix
CFAMM00017412 CHEMBL446077 Bioactive (4R,7S,10S,13R,16S,19S)-19-[[(2R)-2-amino-3-(4-chlorophenyl)propanoyl]amino]-N-[(2S)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-10-[4-(methylamino)butyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
CFAMM00017309 CHEMBL1251 Bioactive Ganirelix
CFAMM00017355 CHEMBL510755 Bioactive (4R,7S,10S,13R,16S,19S)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-(4-chlorophenyl)propanoyl]amino]-N-[(2S)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
CFAMM00017347 CHEMBL437672 Bioactive CHEMBL437672
CFAMM00017325 CHEMBL2311098 Bioactive (4R,7S,10S,13R,16S,19S)-10-(4-aminobutyl)-19-[[(2S)-2-amino-3-(4-chlorophenyl)propanoyl]amino]-N-[(2S)-1-amino-3-naphthalen-2-yl-1-oxopropan-2-yl]-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
CFAMM00017337 CHEMBL262825 Bioactive CHEMBL262825

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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