CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD880
Family Name Aldehyde oxidase Inhibitor Isovanillin Family
No. of Seeds 6 No. of Other Members 429
Family Centroid CFAMM00109446 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Aldehyde oxidase Inhibitor Isovanillin Superfamily
Class Class 663

Cousin Family NamesSeedsMembers
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Peroxisome proliferator-activated receptor alpha Ligand Fenofi... 3 127
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Muscarinic acetylcholine receptor Ligand Mebeverine Family 2 27
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
Danthron family 11 141
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Chromomycin A3 family 7 14
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Endothelin-1 receptor Ligand PD156707 Family 41 211
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU78300 F... 1 2
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Poly [ADP-ribose] polymerase 1 Inhibitor 3-methoxybenzamide Fa... 2 23
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Steryl-sulfatase Inhibitor 4-sulfamoyloxy-benzoic Acid Hexyl E... 11 1
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
Protein kinase C alpha type and Protein kinase C beta type Inh... 7 1
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Tubulin beta chain Inhibitor Combretastatin Family 3 5
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 4 102
Tyrosine-protein phosphatase non-receptor type 1 Ligand Phelli... 1 1
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Protein kinase C alpha type and Protein kinase C beta type Inh... 2 1
Protein kinase C alpha type Inhibitor Acetoside Family 5 39
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Squalene monooxygenase Inhibitor Octyl_gallate Family 5 5
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Neutrophil elastase Inhibitor E-6-o-p-methoxycinnamoyl Scandos... 2 68
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Tyrosine-protein phosphatase non-receptor type 1 Ligand Formyl... 1 1
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 6
Heat shock cognate 71 kDa protein Inhibitor NSC-119913 Family 2 1
Arachidonate 5-lipoxygenase Inhibitor 4,5-dimethoxy-10h-anthra... 1 4
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-b... 6 21
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Acetylcholinesterase Inhibitor 4-formylphenyl-o-beta-d-ribopyr... 2 17
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Prostaglandin G/H synthase 2 Inhibitor Neolignan 9-nor-7,8-deh... 1 7
Amine oxidase [flavin-containing] B Inhibitor Methyl Piperate ... 1 19
72 kDa type IV collagenase Inhibitor Lithospermic Acid Family 1 0
Isocitrate lyase Inhibitor Bis(3-bromo-4,5-dihydroxyphenyl)met... 1 2
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Aromatase inhibitor (3R,4R)-4-benzyl-3-[(3-hydroxyphenyl)methy... 1 10
ELAV-like protein 1 and Myosin light chain kinase, smooth musc... 1 32
Acetylcholinesterase inhibitor AGN-PC-003A5N family 3 9
Amine oxidase [flavin-containing] B inhibitor 5-(4,4,4-trifluo... 2 9
Histamine H1 receptor ligand Ahr 5333 family 1 6
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Cocaine esterase and Liver carboxylesterase 1 inhibitor 2-Chlo... 1 5
Peroxisome proliferator-activated receptor delta and Peroxisom... 4 2
Protein kinase C alpha type inhibitor [2-(hydroxymethyl)-5-oxo... 2 4
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 8
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
Histone deacetylase 2 and Histone deacetylase 8 inhibitor AC1L... 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
Transthyretin inhibitor AGN-PC-046XQV family 1 6
Acetylcholinesterase and Butyrylcholinesterase inhibitor 2-[4-... 3 2
Acetylcholinesterase inhibitor 5,7-Dimethoxy-2-methyl-indan-1-... 1 0
Protein kinase C alpha type inhibitor [(1R)-4-dodecoxy-1-(hydr... 1 18
Platelet-activating factor receptor ligand (2S,3R,3aS)-2-(3,4-... 2 7
Enoyl-[acyl-carrier-protein] reductase [NADPH] inhibitor 4-(4-... 1 1
Heat shock protein HSP 90-alpha inhibitor Catalposide family 5 22
Estrogen receptor beta and Mitogen-activated protein kinase 1 ... 1 2
Thyroid hormone receptor beta and Lysine-specific demethylase ... 1 2
Estradiol 17-beta-dehydrogenase 1 inhibitor SureCN4589665 family 2 4
Putative fructose-1,6-bisphosphate aldolase and Retinal dehydr... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 4
Cholesteryl ester transfer protein inhibitor [8-[(1S)-1-hydrox... 4 10
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Indoleamine 2,3-dioxygenase 1 inhibitor AGN-PC-04S2CP family 1 3
Arachidonate 5-lipoxygenase inhibitor 5-(1,3-benzodioxol-5-yl)... 2 2
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Fyn in... 1 2
Catechol O-methyltransferase inhibitor 4,5-dihydroxybenzene-1,... 1 1
Cholesteryl ester transfer protein inhibitor [8-[(1S)-1-hydrox... 1 0
Integrase inhibitor AC1NX3RZ family 1 0
3-phosphoshikimate 1-carboxyvinyltransferase inhibitor 2-[5-ca... 1 0
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Prenol Lipids Metabolite Scutigeral Family 1 0
Benzopyrans Metabolite (-)-trans-3,4-Dihydro-4,8-dihydroxy-3-m... 1 0
Prenol Lipids Metabolite 13-Hydroxydihydromelleolide Family 3 0
Benzoic Acid and Derivatives Metabolite Methyl 3-(2,3-dihydrox... 1 3
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Phenols and Derivatives Metabolite 6-Gingesulfonic acid Family 1 2
Prenol Lipids Metabolite Rosmadial Family 1 0
Indenes and Isoindenes Metabolite Coixinden B Family 1 0
Acenes Metabolite Musanolone D Family 2 1
Putative NP ZINC31165975 Family 4 0
Putative NP ZINC31158464 Family 3 5
2-benzoyl-3-(3,4-dimethoxyphenyl)-2-ethylcyclopropane-1,1-dica... 4 0
1,3-dimethylcyclohepta[c]furan-8-one NP 6-(4-hydroxy-3-iodo-5-... 13 1
7,8-dimethoxy-1-oxoisothiochromene-3-carboxylate NP Methyl 7,8... 2 0
benzofuran-2-one NP 5-hydroxybenzofuran-2(3h)-one Family 1 0
[(2R,3R,4S,5R,6S)-3-acetyloxy-6-[2-(4-methoxyphenyl)-2-oxoethy... 1 1
(E)-3-(3,4-dimethoxyphenyl)-1-(furan-2-yl)prop-2-en-1-one NP (... 1 0
NP 4-(2,3,4-trimethoxyphenyl)-3,4-dihydro-2h-benzo[g]chromene-... 2 1
2-[(3,4-dimethoxyphenyl)methyl]propanedioate NP 4aji Family 1 0
NP (2r,3r,4s,5r,6s)-2-(acetoxymethyl)-6-(2-propionylphenoxy)te... 2 3
NP 4-(3,4-dimethoxyphenyl)-4-oxo-2-(3,4,5-trimethoxyphenyl)but... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00109446 DAP001393 Approved Drug Isovanillin
CFAMM00109999 CHEMBL129160 Bioactive (E)-3-(3,4-dihydroxyphenyl)-1-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
CFAMM00109789 DNC010452 Investigative Drug Syringic Acid
CFAMM00109650 DNC009130 Investigative Drug 3-hydroxy-2-methoxybenzaldehyde
CFAMM00109420 DNC006146 Investigative Drug VANILLIN
CFAMM00110231 DNC013890 Investigative Drug CYLINDOL A

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

54364 visits since 2014 .........

 


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 
Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543