CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD881
Family Name 5-hydroxytryptamine 2 receptor Ligand Ketanserin Family
No. of Seeds 10 No. of Other Members 253
Family Centroid CFAMM00110446 Functional Category Approved Drug with Natural Product
Superfamily 5-hydroxytryptamine 2 receptor Ligand Ketanserin Superfamily
Class Class 664

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Integrin alpha-4 Inhibitor R1295 Family 18 59
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
K-604 family 4 71
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 9 19
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Extracellular calcium-sensing receptor Ligand 3-phenethyl-2-ph... 3 137
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Arachidonate 5-lipoxygenase Inhibitor Isaindigotone Family 1 0
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor Benz... 3 12
cAMP-specific 3',5'-cyclic phosphodiesterase 4B Inhibitor 3-(2... 2 2
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
D(2) dopamine receptor Ligand PD-168077 Family 6 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 4
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 8
Disintegrin and metalloproteinase domain-containing protein 17... 1 2
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
C-C chemokine receptor type 3 ligand SureCN6704607 family 3 22
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)et... 2 9
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
DNA-(apurinic or apyrimidinic site) lyase and Niemann-Pick C1 ... 1 1
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 16 6
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Bifunctional epoxide hydrolase 2 inhibitor 1-(3-acetylphenyl)-... 1 3
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor SureC... 3 8
Phospholipase D1 and Phospholipase D2 inhibitor 4-bromo-N-[(2S... 1 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
C-C chemokine receptor type 3 ligand AGN-PC-075BAT family 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor AC1N6ZLA family 1 0
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 4 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Mitogen-activated protein kinase 14 and Serine/threonine-prote... 1 1
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZK family 3 0
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Beta-lactamase inhibitor (1R,5S)-4-[(4-carbamoylphenyl)carbamo... 3 2
Glucose-dependent insulinotropic receptor ligand AGN-PC-04UO8L... 2 2
Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quin... 4 16
Histone deacetylase 1 inhibitor 2-[4-[(2-aminophenyl)carbamoyl... 1 1
Multidrug resistance protein 1 inhibitor AGN-PC-07R6HU family 1 0
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 12
1,3,3,5-tetramethylspiro[indole-2,6'-piperidine]-2'-one NP 1,3... 2 0
Putative NP ZINC06549259 Family 2 0
Putative NP ZINC40310029 Family 8 0
2',2'-dimethylspiro[1,3-dihydroquinazoline-2,4'-oxane]-4-one N... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00110446 DAP001394 Approved Drug Ketanserin
CFAMM00110598 CHEMBL1744162 Bioactive 3-[2-(4-benzoylpiperidin-1-yl)ethyl]-1H-quinazoline-2,4-dione;(Z)-but-2-enedioic acid
CFAMM00110305 CHEMBL1628637 Bioactive [3H]KETANSERIN
CFAMM00110304 CHEMBL342413 Bioactive AC1MJ7FR
CFAMM00110405 DNC013514 Investigative Drug ALTANSERIN
CFAMM00110641 DNC007333 Investigative Drug KKHT-10608
CFAMM00110692 DPR000019 Investigative Drug Belaperidone
CFAMM00110640 DNC007334 Investigative Drug KKHT-10609
CFAMM00110639 DNC007335 Investigative Drug KKHT-10613
CFAMM00110580 DNC009274 Investigative Drug 3-Phenyl-1-propylquinazoline-2,4(1H,3H)-dione

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27255 visits since 2014 .........

 


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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