CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD882
Family Name High affinity nerve growth factor receptor Ligand Lestaurtinib Family
No. of Seeds 6 No. of Other Members 126
Family Centroid CFAMM00110775 Functional Category Approved Drug
Superfamily High affinity nerve growth factor receptor Ligand Lestaurtinib Superfamily
Class Class 665

Cousin Family NamesSeedsMembers
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
B-lymphocyte antigen CD20 Inhibitor Rituxan Immunology Family 10 17
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
NF-kappa-B and Protein kinase C zeta type Inhibitor Go6976 Family 9 71
DNA topoisomerase 1 Inhibitor KT6006 Family 3 53
Vascular endothelial growth factor receptor 2 Ligand Isoindoli... 11 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 4 1
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Protein kinase C alpha type and Protein kinase C delta type in... 4 37
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Tyrosine-protein kinase JAK3 inhibitor CHEMBL234066 family 1 2
Protein kinase C alpha type and Protein kinase C delta type in... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00110775 DAP001395 Approved Drug Lestaurtinib
CFAMM00110844 CHEMBL491263 Bioactive CHEMBL491263
CFAMM00110831 CHEMBL2113064 Bioactive CHEMBL2113064
CFAMM00110841 DCL000016 Clinical Trial Drug UCN-01
CFAMM00110858 DCL000165 Clinical Trial Drug Midostaurin
CFAMM00110756 DNC000402 Investigative Drug CEP-751

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27160 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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