CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family
No. of Seeds 9 No. of Other Members 51
Family Centroid CFAMM00111955 Functional Category Approved Drug with Natural Product
Superfamily Fumarate reductase inhibitor Oxantel , adrenergic receptor ligand Salmeterol Superfamily
Class Class 671

Cousin Family NamesSeedsMembers
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Sodium channel protein type 5 subunit alpha Ligand Hexylcaine ... 4 94
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
C-C chemokine receptor type 2 Ligand CCX915 Family 3 25
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Tyrosine-protein phosphatase non-receptor type 1 Ligand PNU177... 1 5
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 18
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 0
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Prostaglandin E2 receptor EP4 subtype ligand 4-[(1S)-1-[[2-(tr... 2 1
Peroxisome proliferator-activated receptor delta and Peroxisom... 13 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 15 13
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 1 3
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 16 2
Beta-3 adrenergic receptor ligand 5-[[(7S)-7-[[(2R)-2-(3-chlor... 6 3
Beta-3 adrenergic receptor ligand 4-[4-[2-[[(2R)-2-(4-aminophe... 3 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-074R8E family 2 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 4 3
Malate dehydrogenase, mitochondrial and Lactate dehydrogenase ... 1 1


External ID

Functional Category

Molecule Name

CFAMM00111955 DAP001426 Approved Drug Salmeterol xinafoate
CFAMM00111971 CHEMBL273006 Bioactive 4-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-2-phenoxybenzoic acid
CFAMM00111968 CHEMBL509156 Bioactive 2-cyclohexyloxy-4-[4-[(2R)-2-[[(2R)-2-hydroxy-2-phenylethyl]amino]propyl]phenyl]benzoic acid
CFAMM00111928 CHEMBL460256 Bioactive 4-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethoxy]phenyl]-2-propoxybenzoic acid
CFAMM00111934 CHEMBL516785 Bioactive 4-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethoxy]phenyl]-2-propan-2-yloxybenzoic acid
CFAMM00111947 CHEMBL409718 Bioactive 2-cyclohexyloxy-4-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]benzoic acid
CFAMM00111920 CHEMBL271401 Bioactive 4-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-2-(oxan-4-yloxy)benzoic acid
CFAMM00111972 CHEMBL459862 Bioactive 2-cyclohexyloxy-4-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethoxy]phenyl]benzoic acid
CFAMM00111932 CHEMBL510100 Bioactive SureCN5668995

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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