CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD894
Family Name 5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family
No. of Seeds 2 No. of Other Members 15
Family Centroid CFAMM00111993 Functional Category Approved Drug
Superfamily 5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Superfamily
Class Class 51

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta adrenergic receptor Ligand Metipranolol Family 5 1
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Histamine H1 receptor Ligand Diphenhydramine Family 5 75
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Salicin family 5 629
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
D(3) dopamine receptor Ligand U-99194A Family 7 33
Vernakalant family 1 1
Acolbifene family 10 115
Dapoxetine family 3 40
TS-071 family 8 36
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Extracellular calcium-sensing receptor and Potassium voltage-g... 3 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Renin Inhibitor Ro-65-7219 Family 10 8
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Estrogen receptor and Estrogen receptor beta ligand (2R,3R,4S)... 3 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL1... 5 5
Histamine H3 receptor ligand 1'-cyclobutyl-6-(1-ethylsulfonylp... 7 10
5-hydroxytryptamine receptor 1A ligand oxalic acid;(1R,5S)-5-[... 2 0
Histamine H3 receptor ligand 1-[4-(1'-cyclobutylspiro[3,4-dihy... 4 0
Histamine H3 receptor ligand SureCN6071181 family 2 1
C-C chemokine receptor type 3 and Histamine H1 receptor ligand... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Cathepsin B and Cathepsin S inhibitor (4S,5R)-4-(2,3-dimethylp... 1 1
Sodium-dependent noradrenaline transporter and Cytochrome P450... 11 2
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 0
Synaptic vesicular amine transporter inhibitor (2R)-3-[(2R,5S)... 1 1
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Histamine H3 receptor ligand (NE)-N-[2-[2-(dimethylamino)ethox... 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00111993 DAP001427 Approved Drug Sarpogrelate
CFAMM00111990 CHEMBL52242 Bioactive AC1MIJ88

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27744 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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