CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Retinoic acid receptor ligand retinoid Isotretinoin Family
No. of Seeds 9 No. of Other Members 29
Family Centroid CFAMM00001759 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Retinoic acid receptor ligand retinoid Isotretinoin Superfamily
Class Class 9

Cousin Family NamesSeedsMembers
Cellular retinoic acid-binding protein 1 and Cellular retinoic... 2 5
Fatty Acids and Conjugates Metabolite 2-Octenoic acid Family 5 10
Prenol Lipids Metabolite Semi-beta-carotenone Family 1 2
Fatty Acids and Conjugates Metabolite trans-Dec-2-enoic acid F... 5 2
Fatty Acids and Conjugates Metabolite Valerenic acid Family 1 1
Fatty Acids and Conjugates Metabolite (2E,4E)-2,7-Dimethyl-2,4... 1 2
Prenol Lipids Metabolite Retinol acetate Family 2 2


External ID

Functional Category

Molecule Name

CFAMM00001759 DAP000009 Approved Drug Isotretinoin
CFAMM00001754 DAP000275 Approved Drug Alitretinoin
CFAMM00001784 DAP001221 Approved Drug Tretinoin
CFAMM00001750 CHEMBL44478 Bioactive 4759-48-2
CFAMM00001743 CHEMBL46398 Bioactive (2E,4E,6E,8E)-8-(3-ethyl-2-propan-2-ylcyclohex-2-en-1-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid
CFAMM00001785 CHEMBL75548 Bioactive (2Z,5E)-7-methyl-3-[(E)-2-(2,6,6-trimethylcyclohexen-1-yl)ethenyl]nona-2,5-dienoic acid
CFAMM00001746 CHEMBL74331 Bioactive (2E,4E)-3-methyl-5-[2-[(E)-2-(3,3,6,6-tetramethylcyclohexen-1-yl)ethenyl]cyclopropyl]penta-2,4-dienoic acid
CFAMM00001741 CHEMBL122823 Bioactive (2E,4E,6E,8E)-8-(2,3-dimethylcyclohex-2-en-1-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid
CFAMM00001783 CHEMBL333032 Bioactive (2E,4E,6E,8E)-3,7-dimethyl-8-(3-methyl-2-propan-2-ylcyclohex-2-en-1-ylidene)octa-2,4,6-trienoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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