CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name xanthine alkaloid Theobromine family
No. of Seeds 6 No. of Other Members 10
Family Centroid CFAMM00017965 Functional Category Approved Drug with Natural Product
Superfamily cAMP-specific 3',5'-cyclic phosphodiesterase, TNF inhibitor xanthine derivative Superfamily
Class Class 2

Cousin Family NamesSeedsMembers
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor xant... 18 210
Tumor necrosis factor inhibitor xanthine derivative Pentoxifyl... 5 69
DNA polymerase inhibitor guanosine analog Aciclovir Family 4 41
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor xant... 3 7
Adenosine receptor A1 Ligand MK-7418 Family 21 116
Adenosine receptor A2a Ligand BG-9928 Family 8 11
UDP-N-acetylglucosamine 1-carboxyvinyltransferase Inhibitor RW... 1 0
Purine nucleoside phosphorylase Inhibitor 9-(5,5-difluoro-5-ph... 1 16
Purine nucleoside phosphorylase Inhibitor 8-iodo-guanine Family 2 3
Hypoxanthine-guanine-xanthine phosphoribosyltransferase Inhibi... 3 7
Adenosine receptor A1 Ligand 7-(3,6,9,12-tetraoxatricos-22-eny... 1 1
Purine nucleoside phosphorylase inhibitor [(3R,4S)-3-(2-amino-... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand NSC14... 1 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Adenosine receptor A1 and Adenosine receptor A2b ligand 8-(1-$... 2 2
Dipeptidyl peptidase 4 inhibitor SureCN554974 family 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 1 0


External ID

Functional Category

Molecule Name

CFAMM00017972 DAP000987 Approved Drug Temozolomide
CFAMM00017971 DAP000099 Approved Drug Caffeine
CFAMM00017965 DNAP001596 Approved Drug Theobromine
CFAMM00017980 DNC000816 Investigative Drug Iso-caffeine
CFAMM00017967 DNC002953 Investigative Drug 9-Methylguanine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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