CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD901
Family Name Oestrogen receptor Ligand Lasofoxifene Family
No. of Seeds 19 No. of Other Members 152
Family Centroid CFAMM00112254 Functional Category Approved Drug
Superfamily Oestrogen receptor Ligand Lasofoxifene Superfamily
Class Class 142

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Oestrogen receptor Ligand Raloxifene Family 4 169
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
D(3) dopamine receptor Ligand U-99194A Family 7 33
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Vernakalant family 1 1
Acolbifene family 10 115
Dapoxetine family 3 40
TS-071 family 8 36
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Oestrogen receptor and Tyrosine-protein phosphatase non-recept... 92 21
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Renin Inhibitor Ro-65-7219 Family 10 8
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 20 0
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 1
Estrogen receptor and Estrogen receptor beta ligand CHEMBL1087... 2 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Leukotriene A-4 hydrolase inhibitor SureCN13809114 family 2 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Estrogen receptor and Estrogen receptor beta ligand (2S,3R)-2-... 3 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
D(3) dopamine receptor ligand S 14297 family 1 2
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 2
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 12 0
Estrogen receptor and Estrogen receptor beta ligand (2R,3R,4S)... 3 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL1... 5 5
5-hydroxytryptamine receptor 1A ligand oxalic acid;(1R,5S)-5-[... 2 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 3 0
Estrogen receptor ligand (8S,9R,11S,13S,14S,17S)-11-[4-[2-[2-(... 1 4
Histamine H3 receptor ligand SureCN6071181 family 2 1
Sodium-dependent serotonin transporter and Alpha-2A adrenergic... 2 2
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Estrogen receptor and Estrogen receptor beta ligand SureCN3115... 9 0
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00E... 7 1
Estrogen receptor and Estrogen receptor beta ligand SureCN1450... 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 0
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Cathepsin B and Cathepsin S inhibitor (4S,5R)-4-(2,3-dimethylp... 1 1
Estrogen receptor and Estrogen receptor beta ligand SureCN6716... 2 0
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7450653... 1 0
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Estrogen receptor and Estrogen receptor beta ligand SureCN8476... 2 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Muscleblind-like protein 1 and Ferritin light chain inhibitor ... 1 1
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00S... 1 1
Peroxisome proliferator-activated receptor gamma ligand 2-etho... 6 2
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Sigma non-opioid intracellular receptor 1 ligand tert-butyl 2-... 1 1
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 1 0
Histamine H3 receptor ligand (NE)-N-[2-[2-(dimethylamino)ethox... 3 2
Putative NP ZINC04061066 Family 18 0
NP 1-(7-hydroxyspiro[chroman-2,4'-piperidin]-1'-yl)ethanone Fa... 2 0
Putative NP ZINC33933789 Family 4 0
NP N-(4-chlorobenzyl)-n-(3-(4-isopropoxyphenyl)-3-phenylpropyl... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00112254 DAP001445 Approved Drug Lasofoxifene
CFAMM00112237 CHEMBL540584 Bioactive SureCN6246678
CFAMM00112215 CHEMBL433581 Bioactive SureCN6689360
CFAMM00112208 CHEMBL197495 Bioactive (5R,6S)-6-phenyl-5-[4-[(2S)-2-pyrrolidin-1-ylpropoxy]phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
CFAMM00112221 CHEMBL267385 Bioactive SureCN6286153
CFAMM00112295 CHEMBL381645 Bioactive 2-(4-hydroxyphenyl)-1-[4-(2-piperidin-1-ylethoxy)phenyl]-3H-inden-5-ol
CFAMM00112274 CHEMBL181936 Bioactive CHEBI:41593
CFAMM00112212 CHEMBL317748 Bioactive SureCN3774585
CFAMM00112164 CHEMBL539849 Bioactive SureCN3861324
CFAMM00112240 CHEMBL162432 Bioactive 1-[2-[4-(4-phenylphenoxy)phenoxy]ethyl]pyrrolidine
CFAMM00112253 CHEMBL183333 Bioactive (3S,4R)-3-phenyl-4-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-3,4-dihydro-1H-isothiochromen-7-ol
CFAMM00112266 CHEMBL369724 Bioactive (2R,3R,4S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy]phenyl]-3,4-dihydro-2H-chromen-6-ol
CFAMM00112272 CHEMBL92748 Bioactive SureCN117915
CFAMM00112265 CHEMBL437695 Bioactive (5R,6S)-5-[4-[2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy]phenyl]-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol
CFAMM00112210 CHEMBL2113002 Bioactive (2R,3R,4S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[(2R)-1-pyrrolidin-1-ylpropan-2-yl]oxyphenyl]-3,4-dihydro-2H-chromen-6-ol
CFAMM00112238 CHEMBL183162 Bioactive (3S,4R)-3-phenyl-4-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-3,4-dihydro-1H-isochromen-7-ol
CFAMM00112135 DNC012292 Investigative Drug NAFOXIDINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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