CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name D(2) dopamine receptor Ligand phenothiazine analog Prochlorperazine Family
No. of Seeds 4 No. of Other Members 25
Family Centroid CFAMM00017992 Functional Category Approved Drug with Human Metabolite
Superfamily D(2) dopamine receptor Ligand Prochlorperazine Superfamily
Class Class 87

Cousin Family NamesSeedsMembers
Alpha adrenergic receptor ligand phenothiazine derivative Thio... 4 10
Muscarinic acetylcholine receptor M5 ligand phenothiazine deri... 8 37
Histamine H1 receptor ligand phenothiazine derivative Mequitaz... 3 2
5-hydroxytryptamine receptor Ligand Lu AA21004 Family 13 39
5-hydroxytryptamine receptor 6 Ligand 4-(4-benzenesulfonamidop... 4 5
Cholinesterase Inhibitor N-cyclohexyl-1'h-phenothiazine-1'-car... 7 2
Trypanothione reductase Inhibitor N-(5-chloro-2-(phenylthio)ph... 1 1
Neuropeptide Y receptor type 5 ligand FR-235656 family 4 3
5-hydroxytryptamine receptor 2A and Alpha-2B adrenergic recept... 1 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Sigma non-opioid intracellular receptor 1 ligand 3-[4-(azepan-... 8 1


External ID

Functional Category

Molecule Name

CFAMM00017992 DAP000373 Approved Drug Prochlorperazine
CFAMM00017993 DAP000374 Approved Drug Chlorpromazine
CFAMM00017998 DAP000100 Approved Drug Perphenazine
CFAMM00018011 CHEMBL1713 Bioactive Chlorpromazine hydrochloride

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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