CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD911
Family Name Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00112560 Functional Category Approved Drug
Superfamily Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Superfamily
Class Class 684

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Opioid receptor ligand opiate Levorphanol Family 18 537
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Oestrogen receptor ligand Dienestrol Family 35 440
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Histamine H1 receptor Ligand Chlophedianol Family 4 46
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
CORT-108297 family 46 44
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Acetylcholinesterase and Cholinesterase Inhibitor N,n'-(1',10'... 12 8
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
4-aminobutyrate aminotransferase, mitochondrial Inhibitor 4-hy... 2 6
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
Glutamate receptor ionotropic, NMDA 3A and Glutamate receptor ... 2 1
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
D(2) dopamine receptor and D(1A) dopamine receptor ligand (2R,... 3 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
D(1A) dopamine receptor ligand (5S)-5-(4-azidophenyl)-8-iodo-3... 2 0
D(1A) dopamine receptor ligand (5R)-8-bromo-3-methyl-5-phenyl-... 6 15
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00112560 DAP001469 Approved Drug Desvenalfaxine succinate
CFAMM00112563 DCL000768 Clinical Trial Drug Desvenlafaxine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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