CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD917
Family Name Acyl-CoA desaturase Inhibitor Isoxyl Family
No. of Seeds 5 No. of Other Members 62
Family Centroid CFAMM00112779 Functional Category Approved Drug
Superfamily Acyl-CoA desaturase Inhibitor Isoxyl Superfamily
Class Class 690

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Histamine H3 receptor Ligand UCL1972 Family 3 23
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Substance-K receptor Ligand MEN-14933 Family 13 154
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Histone deacetylase 1 Inhibitor 7-(4-(dimethylamino)phenoxy)-n... 2 1
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 11 13
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 10 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN2729784 family 3 9
Transient receptor potential cation channel subfamily V member... 3 15
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor SureCN... 2 11
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 11 12
Dihydrofolate reductase inhibitor 10-[3-(4-nitrophenoxy)propox... 1 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 4 19
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 6 3
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 8 4
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 10 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(2... 2 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 8
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 3 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 1 0
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
Lysophosphatidic acid receptor 2 and Lysophosphatidic acid rec... 1 0
Histamine H3 receptor ligand AGN-PC-077MDJ family 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Prostacyclin receptor ligand CAY10441 family 1 0
Hormone-sensitive lipase and Acetylcholinesterase inhibitor Su... 2 0
Dihydrofolate reductase inhibitor 4-[[4-(4,6-diamino-2,2-dimet... 1 1
Nitric oxide synthase, brain inhibitor AC1PDE4K family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00112779 DAP001485 Approved Drug Isoxyl
CFAMM00112739 CHEMBL2047804 Bioactive [4-[(4-phenoxyphenyl)carbamoylamino]phenyl] sulfamate
CFAMM00112813 CHEMBL2331762 Bioactive 1-(4-butoxyphenyl)-3-[4-(sulfamoylamino)phenyl]urea
CFAMM00112747 CHEMBL1818420 Bioactive 1,3-bis[4-(3-methylbutoxy)phenyl]urea
CFAMM00112756 DNC011523 Investigative Drug N,N'-Bis-(4-butoxy-phenyl)-guanidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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