CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD92
Family Name Histamine H1 receptor ligand tricyclic antidepressant Loratadine Family
No. of Seeds 5 No. of Other Members 163
Family Centroid CFAMM00018055 Functional Category Approved Drug
Superfamily Histamine H1 receptor ligand tricyclic antidepressant Superfamily
Class Class 88

Cousin Family NamesSeedsMembers
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Substance-P receptor Ligand TAK-637 Family 18 63
ABC294640 family 5 75
C-C chemokine receptor type 5 Ligand Sch 351125 Family 6 29
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
D(4) dopamine receptor Ligand ABT-670 Family 4 14
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Prothrombin inhibitor SureCN7371121 family 13 3
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand [2... 2 5
Histamine H1 receptor and Potassium voltage-gated channel subf... 5 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 3
B1 bradykinin receptor ligand ELN-441958 family 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 4 10
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 10 0
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 8 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Coagulation factor X and Prothrombin inhibitor SureCN8243313 f... 10 8
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Substance-K receptor and Substance-P receptor ligand 3,5-dichl... 3 0
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 2
Glucose-dependent insulinotropic receptor ligand tert-butyl 4-... 2 1
Reverse transcriptase/RNaseH inhibitor (4s)-6-chloro-4-cyclopr... 5 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00018055 DAP000101 Approved Drug Loratadine
CFAMM00018092 DCL000921 Clinical Trial Drug PegCNTF
CFAMM00018149 DNC003528 Investigative Drug SCH-44342
CFAMM00018061 DNC014184 Investigative Drug 1-[(Furan-2(5H)-one)-4-methyl]-desloratadine
CFAMM00018038 DNC001305 Investigative Drug SCH 44643

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21760 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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